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[3H]-NFPS binding to the glycine transporter 1 in the hemi-parkinsonian rat brain
L-3,4-dihydroxyphenylalanine (L-DOPA) is the main treatment for Parkinson’s disease (PD) but with long term administration, motor complications such...
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Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management
Frontocortical NMDA receptors are pivotal in regulating cognition and mood, are hypofunctional in schizophrenia, and may contribute to autistic...
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GlyT1 determines the glycinergic phenotype of amacrine cells in the mouse retina
The amino acid glycine acts as a neurotransmitter at both inhibitory glycinergic and excitatory glutamatergic synapses predominantly in caudal...
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SSR504734 enhances basal expression of prepulse inhibition but exacerbates the disruption of prepulse inhibition by apomorphine
RationaleInhibition of glycine transporter 1 (GlyT1) elevates extracellular glycine and can thus increase N -methyl- d -aspartate receptor (NMDAR)...
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Glutamatergic targets for new alcohol medications
RationaleAn increasingly compelling literature points to a major role for the glutamate system in mediating the effects of alcohol on behavior and...
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Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain
Glycine transporters are endogenous regulators of the dual functions of glycine, which acts as a classical inhibitory neurotransmitter at glycinergic...
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Glycine Transport Inhibitors in the Treatment of Schizophrenia
Schizophrenia is a severe neuropsychiatric disorder without adequate current treatment. Recent theories of schizophrenia focus on disturbances of...
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Prepulse inhibition of the startle reflex and response to antipsychotic treatments in two outbred mouse strains in comparison to the inbred DBA/2 mouse
RationaleNaturally low prepulse inhibition (PPI) in DBA/2 mice is increased by marketed antipsychotics and compounds acting at novel targets relevant...
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Glycine enhances microglial intracellular calcium signaling. A role for sodium-coupled neutral amino acid transporters
The inhibitory neurotransmitter glycine is known to enhance microglial nitric oxide production. However, up to now, the mechanism is undocumented....
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Inhibition of Glycine Transporter-1 Improves the Functional Outcome of Schizophrenia
Although current antipsychotic medications are able to reduce psychotic symptoms by blocking dopamine 2 (D2) receptors, they are limited in their...
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Glycine Transporters and Their Inhibitors
Glycine plays a ubiquitous role in many biological processes. In the central nervous systemit serves as an important neurotransmitter acting as an...
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Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia
RationaleSchizophrenic patients demonstrate prominent negative and cognitive symptoms that are poorly responsive to antipsychotic treatment. Abnormal...
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Slow glycinergic transmission mediated by transmitter pooling
Most fast-acting neurotransmitters are rapidly cleared from synaptic regions. This feature isolates synaptic sites, rendering the time course of...
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Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat
RationaleSSR103800 and SSR504734 are novel glycine transport 1 (GlyT1) inhibitors with therapeutic potential for the treatment of schizophrenia.
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Realistic expectations of prepulse inhibition in translational models for schizophrenia research
IntroductionUnder specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the startling effects of a subsequent intense abrupt...
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Modulators of the glycine site on NMDA receptors, d-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
RationaleSchizophrenia is characterized by disturbances in sensorimotor gating and attentional processes, which can be measured by prepulse...
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Pharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands
RationaleAccumulating evidence suggests that drugs acting on the glutamatergic system may represent promising novel therapeutic targets for the...
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Substance use disorders and schizophrenia: A question of shared glutamatergic mechanisms
Schizophrenia is noted for the remarkably high prevalence of substance use disorders (SUDs) including nicotine (>85%), alcohol and stimulants....
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N-Methyl-d-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives
RationaleActivation of “co-agonist” N -methyl- d -aspartate (NMDA) and Glycine B sites is mandatory for the operation of NMDA receptors, which play an...
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Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6
The SLC6 family is a diverse set of transporters that mediate solute translocation across cell plasma membranes by coupling solute transport to the...
