Search
Search Results
-
Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
BackgroundAging and sex are major risk factors for develo** late-onset Alzheimer’s disease. Compared to men, women experience worse...
-
Decrease in naturally occurring antibodies against epitopes of Alzheimer’s disease (AD) risk gene products is associated with cognitive decline in AD
BackgroundNaturally occurring antibodies (NAbs) are germline-encoded immunoglobulins that can bind to and clear out self-neo-epitopes as well as...
-
AD Blank Spot Model for Evaluation of Alzheimer’s Disease
The discovery of biomarkers that confer high confidence of Alzheimer’s disease (AD) diagnosis and disease management would be a valuable tool to...
-
AD Blank Spot Model for Evaluation of Alzheimer’s Disease
The discovery of biomarkers that confer high confidence of Alzheimer’s disease (AD) diagnosis and disease management would be a valuable tool to...
-
Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)
BackgroundMultimodal lifestyle interventions can benefit overall health, including cognition, in populations at-risk for dementia. However, little is...
-
Emerging Nanotechnology for the Treatment and Diagnosis of Parkinson’s Disease (PD) and Alzheimer’s Disease (AD)
Introduction: Parkinson’s disease (PD)Parkinson’s disease and Alzheimer’s disease (AD)Alzheimer’s disease are neurodegenerative diseases...
-
Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer’s disease rat model as a measure of early network alterations
This study investigates brain network alterations in the default mode-like network (DMLN) at early stages of disease progression in a rat model of...
-
Alzheimer’s Disease
Alzheimer’s disease is a dramatic pathological occurrence for the patient, his family, caregivers and doctors.
-
Metabolic Disease and Alzheimer’s Disease
Age-related diseases (ARDs) include inflammatory atherosclerosis and cardiovascular disease in coronary artery disease (CAD), hypertension, type 2...
-
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is notably associated with cognitive decline resulting from impaired function of hippocampal and cortical areas;...
-
Deciphering Drug Targets for Alzheimer’s Disease
This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on...
-
Epigenetic Therapy for Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no effective treatments. Increasing evidence suggests that the epigenetic...
-
Neuroinflammation in Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the significant progressive disorders of the brain, which lead to the destruction of memory and cognitive power in...
-
Gene therapy: an alternative to treat Alzheimer’s disease
Alzheimer’s disease (AD), a neuro-degenerative disease that primarily affects the elderly, is a worldwide phenomenon. Loss of memory, cognitive...
-
The mitochondrial protein TSPO in Alzheimer’s disease: relation to the severity of AD pathology and the neuroinflammatory environment
The 18kD translocator protein (TSPO) is used as a positron emission tomography (PET) target to quantify neuroinflammation in patients. In Alzheimer’s...
-
Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks
Mitochondrial dysfunctions are key features of Alzheimer’s disease (AD). The occurrence of these disturbances in the peripheral cells of AD patients...
-
Drug Delivery Strategies in Alzheimer’s Disease
Over the past few decades, a concern over neurodegenerative disorders is growing proportionately with age, changing lifestyles, hereditary...
-
Characterization of preclinical Alzheimer’s disease model: spontaneous type 2 diabetic cynomolgus monkeys with systemic pro-inflammation, positive biomarkers and develo** AD-like pathology
BackgroundThe key to the prevention and treatment of Alzheimer’s disease (AD) is to be able to predict and diagnose AD at the preclinical or early...
-
Computational identification of potential acetylcholinesterase (AChE) and monoamine oxidase-B inhibitors from Vitis vinifera: a case study of Alzheimer’s disease (AD)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease that affects people aged 60 years and above. Yet, the discovery of potent...
-
Introduction to Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative ailment associated with intracellular amyloid aggregates and extracellular...