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Adults with tetralogy of Fallot show specific features of cerebral small vessel disease: the BACH San Donato study
Life expectancy in adults with congenital heart disease (ACHD) has increased. As these patients grow older, they experience aging-related diseases...
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T Helper Cells Producing Granulocyte-Macrophage Colony Stimulating Factor as a Risk Marker for Coronary Heart Disease
Coronary heart disease (CHD) is related to aberrant aggregation of immune cells in the plaques. This study focused on identification of abnormal T...
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Brain volumes in adults with congenital heart disease correlate with executive function abilities
Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet,...
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Thymic Atrophy and Immune Dysregulation in Infants with Complex Congenital Heart Disease
Congenital heart disease (CHD) is the most common birth defect, and up to 50% of infants with CHD require cardiovascular surgery early in life....
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Protein Pyrrole Adducts in Diabetes Mellitus
Diabetes mellitus is commonly associated with a symmetrical, distal sensory or sensorimotor axonal polyneuropathy that develops insidiously and...
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Machine Learning in Cardiovascular Disorders
Cardiovascular Diseases, affecting human lives and claiming lives globally is a matter of concern globally. Although conventional methods are in use,...
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Protein Pyrrole Adducts in Diabetes Mellitus
Diabetes mellitus is commonly associated with a symmetrical, distal sensory or sensorimotor axonal polyneuropathy that develops insidiously and...
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Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation
Vesicular glutamate transporters (VGLUTs) control quantal size of glutamatergic transmission and have been the center of numerous studies over the...
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The protective microRNA-199a-5p-mediated unfolded protein response in hypoxic cardiomyocytes is regulated by STAT3 pathway
The protective effects of downregulated miR-199a-5p on ischemic and hypoxic cardiomyocytes were well recognized, but the underlying mechanism of...
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All-cause mortality and survival in adults with 22q11.2 deletion syndrome
PurposeGiven limited data available on long-term outcomes in 22q11.2 deletion syndrome (22q11.2DS), we investigated mortality risk in adults with...
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Epidemiology of Congenital Heart Disease with Emphasis on Sex-Related Aspects
Gender differences in prevalence, manifestation, treatment outcomes, and prognosis have been well known for acquired heart disease such as coronary...
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Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study
BackgroundTo examine serum angiopoietin-2 (Angpt-2) in relation to malnutrition, inflammation, atherosclerosis and cardiac valvular calcification,...
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The genetics and screening of familial hypercholesterolaemia
Familial Hypercholesterolaemia is an autosomal, dominant genetic disorder that leads to elevated blood cholesterol and a dramatically increased risk...
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Genome-wide copy number variant analysis for congenital ventricular septal defects in Chinese Han population
BackgroundVentricular septal defects (VSDs) constitute the most prevalent congenital heart disease (CHD), occurs either in isolation (isolated VSD)...
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Vesicular Glutamate Uptake
Glutamate is an excitatory neurotransmitter widely used in the vertebrate central nervous systems. The synaptic transmission process is characterized...
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A New VGLUT-Specific Potent Inhibitor: Pharmacophore of Brilliant Yellow
The increased concentration of glutamate in synaptic vesicles, mediated by the vesicular glutamate transporter (VGLUT), is an initial vital step in...
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Proteomic risk markers for coronary heart disease and stroke: validation and mediation of randomized trial hormone therapy effects on these diseases
BackgroundWe previously reported mass spectrometry-based proteomic discovery research to identify novel plasma proteins related to the risk of...
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The Glutamate Uptake System in Presynaptic Vesicles: Further Characterization of Structural Requirements for Inhibitors and Substrates
Noncyclic fluorine-substituted and cyclic analogs of glutamic acid were tested for their ability to inhibit glutamate uptake in isolated bovine...
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Fast Kinetics of G-Protein Function In Vivo
The muscarinic receptor-mediated activation of the potassium current IK(ACh) in atrial myocytes is the most extensively studied prototype of the...