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Biomedicine

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Showing 1-20 of 27 results

  1. Comparing the efficacy of regorafenib and 5-fluorouracil-based rechallenge chemotherapy in the third-line treatment of metastatic colorectal cancer

    Background

    The optimal treatment for metastatic colorectal cancer (mCRC) after the second line is still controversial. Regorafenib has been the...

    Elif Şenocak Taşçı, Başak Oyan, ... Mustafa Bozkurt in BMC Cancer
    Article Open access 02 January 2024

  2. Hypoxia in Drug Resistance and Radioresistance

    Tumors mostly experience hypoxia or hypoxic stress as they progress, especially for tumor cells that are located far from the functional blood...
    Kwang-Yu Chang, I-Li Lin, Chun Hei Antonio Cheung in Hypoxia in Cancer: Significance and Impact on Cancer Therapy
    Chapter 2023

  3. Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions

    Background

    Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer....

    Ho-Kai Huang, Yi-Hsin Lin, ... Wen-Tai Chiu in Journal of Biomedical Science
    Article Open access 21 February 2020

  4. Evaluation of Antiproliferative Activity, Safety and Biodistribution of Oxaliplatin and 5-Fluorouracil Loaded Lactoferrin Nanoparticles for the Management of Colon Adenocarcinoma: an In Vitro and an In Vivo Study

    Purpose

    Colon adenocarcinoma is the most common form of gastro intestinal tract cancer, predominantly in ageing population. Chemotherapy with...

    Farhan Ahmed, Sonali Kumari, Anand Kumar Kondapi in Pharmaceutical Research
    Article 16 July 2018

  5. Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer

    Colorectal cancer (CRC) remains one of the leading causes of cancer mortality worldwide. Regarded as a heterogeneous disease, a number of biomarkers...
    Maria Sofia Fernandes, João Miguel Sanches, Raquel Seruca in Targeted Therapy of Colorectal Cancer Subtypes
    Chapter 2018

  7. Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells

    Metformin, an AMPK activator, has been reported to improve pathological response to chemotherapy in diabetic breast cancer patients. To date, its...

    Jaslyn Sian-Siu Soo, Char-Hong Ng, ... Chee-Onn Leong in Apoptosis
    Article 15 August 2015

  8. A single-arm phase II trial of combined chemotherapy with S-1, oral leucovorin, and bevacizumab in heavily pre-treated patients with metastatic colorectal cancer

    Background

    The mean 5–6-month survival after failed standard chemotherapy for metastatic colorectal cancer (mCRC) necessitates more effective...

    Kazuhisa Yamaguchi, Hiroya Taniguchi, ... Yoshinori Igarashi in BMC Cancer
    Article Open access 27 August 2015

  9. CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells

    Melatonin exhibits oncostatic activity in several cancers but does not lead to cytotoxicity in estrogen receptor (ER)-negative non-small cell lung...

    Wootae Kim, Joo-Won Jeong, Ja-Eun Kim in Tumor Biology
    Article 02 August 2014

  10. A comprehensive review of the preclinical efficacy profile of the ErbB family blocker afatinib in cancer

    Afatinib (also known as BIBW 2992) has recently been approved in several countries for the treatment of a distinct type of epidermal growth factor...

    Helmout Modjtahedi, Byoung Chul Cho, ... Flavio Solca in Naunyn-Schmiedeberg's Archives of Pharmacology
    Article Open access 19 March 2014

  11. MicroRNA: a prognostic biomarker and a possible druggable target for circumventing multidrug resistance in cancer chemotherapy

    Multidrug resistance (MDR) is a major obstacle to successful cancer treatment. It is often associated with an increased efflux of a variety of...

    Kenneth KW To in Journal of Biomedical Science
    Article Open access 20 December 2013

  12. Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors

    Background

    CD34 + progenitor cells comprise both hematopoietic and endothelial progenitor cells. Recent studies suggest that circulating endothelial...

    Barbara Vizio, Fiorella Biasi, ... Graziella Bellone in Journal of Translational Medicine
    Article Open access 17 December 2013

  13. Cancer Biomarkers Associated with Damage Response Genes

    The development and validation of prognostic and predictive cancers biomarkers associated with damage response genes is a rapidly moving field....
    Anne E. Kiltie, Marie Fernet, Janet Hall in The DNA Damage Response: Implications on Cancer Formation and Treatment
    Chapter 2009

  14. Colorectal Cancer: Optimization of the Combination of 5-Fluorouracil and Irinotecan

    Colorectal cancer (CRC) is the third lead ing cause of cancer in both men and women worldwide (Goldberg, 2005). Upon diag nosis, 19% of CRC cases are...
    Carlo Barone, Matteo Landriscina, Alessandra Cassano in Colorectal Cancer
    Chapter 2009

  15. Functional Imaging of Multidrug Resistance and Its Applications

    The emergence of multidrug resistance (MDR) is a major obstacle to the success of antineoplastic therapies [1]. The classical mechanism underlying...
    Célia M. F. Gomes in Pharmaceutical Perspectives of Cancer Therapeutics
    Chapter 2009

  16. Targeted Therapies for Prostate Cancer

    Prostate cancer is the second leading cause of cancer deaths in males in the USA. Prostate cancer is a highly morbid disease, especially upon its...
    Elisabeth I. Heath, Michael A. Carducci in Molecular Targeting in Oncology
    Chapter 2008

  18. A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer

    Gemcitabine (GEM)-based chemotherapy is regarded as the standard treatment of pancreatic adenocarcinoma, but yields a very limited disease control....

    A Mercalli, V Sordi, ... L Piemonti in British Journal of Cancer
    Article Open access 10 April 2007

  19. Molecular basis of antifolate resistance

    Folates play a key role in one-carbon metabolism essential for the biosynthesis of purines, thymidylate and hence DNA replication. The antifolate...

    Yehuda G. Assaraf in Cancer and Metastasis Reviews
    Article 27 February 2007
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