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D1R-5-HT2AR Uncoupling Reduces Depressive Behaviours via HDAC Signalling
Dopamine and serotonin signalling are associated with major depressive disorder, which is a prevalent life-threatening illness worldwide. Numerous...
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Serotonin 2C receptors are also important in head-twitch responses in male mice
RationaleSerotonergic psychedelics exert their effects via their high affinity for serotonin (5-HT) receptors, particularly through activating 5-HT2A...
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On the Disbalance and Impairment of Serotonin Heteroreceptor Complexes in the Rat Brain After MDMA and Hallucinogens Administration
The introduction of allosteric receptor–receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the CNS gives a new...
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On the Disbalance and Impairment of Serotonin Heteroreceptor Complexes in the Rat Brain After MDMA and Hallucinogens Administration
The introduction of allosteric receptor–receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the CNS gives a new...
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5-HT 2A and 5-HT 2C receptor antagonism differentially modulate reinforcement learning and cognitive flexibility: behavioural and computational evidence
RationaleCognitive flexibility, the ability to adapt behaviour in response to a changing environment, is disrupted in several neuropsychiatric...
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Modulation of DOM-Induced Head-Twitch Response by mGluR2 Agonist/Inverse Agonist is Associated with 5-HT2AR-Mediated Gs Signaling Pathway
Hallucinogenic 5-HT 2A receptor (5-HT 2A R) agonists-induced head-twitch response (HTR) is regulated by G s signaling pathway. Formation of heterodimers...
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Effects of 5-HT1A Receptor Antagonist and 5-HT2A Receptor Agonist on Morphine Withdrawal
AbstractChronic administration of morphine causes physical dependence, possibly through serotonin 5‑HT 1A receptor (5-HT 1A R) and 5-HT 2A receptor (5-HT
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Disentangling the acute subjective effects of classic psychedelics from their enduring therapeutic properties
Recent research with classic psychedelics suggests significant therapeutic potential, particularly for neuropsychiatric disorders. A mediating...
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Content analysis of Reddit posts about coadministration of selective serotonin reuptake inhibitors and psilocybin mushrooms
RationaleTreatments with the serotonergic psychedelic psilocybin are being investigated for multiple neuropsychiatric disorders. Because many...
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The effects of serotonergic psychedelics in synaptic and intrinsic properties of neurons in layer II/III of the orbitofrontal cortex
RationaleSerotonergic psychedelics show promise in the treatment of psychiatric disorders, including obsessive–compulsive disorder. Dysfunction of...
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Classic Psychedelics in Addiction Treatment: The Case for Psilocybin in Tobacco Smoking Cessation
This manuscript reviews research suggesting that classic psychedelics (5-HT2A receptor agonists) are effective in treating addictions including...
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Heteroreceptor Complexes in Substance Use Disorders
Substance use disorder (SUD) is a chronic and serious brain disorder. Several drugs can lead to addictive behavior including psychostimulants,...
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Heteroreceptor Complexes in Substance Use Disorders
Substance use disorder (SUD) is a chronic and serious brain disorder. Several drugs can lead to addictive behavior including psychostimulants,...
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Probing the antidepressant potential of psilocybin: integrating insight from human research and animal models towards an understanding of neural circuit mechanisms
Interest in the therapeutic potential of serotonergic psychedelic compounds including psilocybin has surged in recent years. While human clinical...
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Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor
New psychoactive substances (NPS) are introduced on the illicit drug market at a rapid pace. Their molecular targets are often inadequately...
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Glutamate, Glutamatergic Drugs and Schizophrenia
Over the past two decades, increasing evidence from preclinical and human studies supports a major role of glutamatergic dysfunction in the...
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Pharmacotherapy and Emerging Treatment Strategies for Schizophrenia
Schizophrenia (ScZ) is a mental condition in which individuals’ views of reality are distorted. Hallucinations, delusions, altered cognition, and...
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The Serotonergic System and Amyotrophic Lateral Sclerosis: A Review of Current Evidence
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the premature death of motor neurons. Serotonin (5-HT) is a...
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Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties
Partial agonist activity at the dopamine D 2 receptor (DRD2) is a key feature of third-generation antipsychotics (TGAs). However, TGAs also act as...
