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Effects of 5-HT1A Receptor Antagonist and 5-HT2A Receptor Agonist on Morphine Withdrawal
AbstractChronic administration of morphine causes physical dependence, possibly through serotonin 5‑HT 1A receptor (5-HT 1A R) and 5-HT 2A receptor (5-HT
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Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor
Selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, are frequently combined with medical psychostimulants such as methylphenidate...
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Tonic serotonergic input increases the burst firing mode and diminishes the firing rate of reticular thalamic nucleus neurons through 5-HT1A receptors activation in anesthetized rats
The reticular thalamic nucleus (RTn) is a thin shell of GABAergic neurons that covers the dorsal thalamus that regulate the global activity of all...
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The Role of 5-HT1A Receptors and Neuronal Nitric Oxide Synthase in a Seizur Induced Kindling Model in Rats
Background and ObjectiveDentate gyrus (DG) has a high density of 5-HT1A receptors. It has neural nitric oxide synthase (nNOS), which is involved in...
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Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson’s Disease
Pain in Parkinson’s disease (PD) is increasingly recognized as a major factor associated with poor life quality of PD patients. However, classic...
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Alterations in Receptor Genes in Huntington’s Disease
In this chapter, we explored the alterations in receptor genes associated with Huntington’s disease (HD). The dysfunction and composition of receptor...
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The Effect of Subchronic Alcoholization on the Behavior and Monoaminergic Systems of the Brains of Mice with a Predisposition to Depression-Like Behavior
Abstract —Depressive disorders and alcohol dependence are among the most common psychopathologies. It is known that disorders in the functioning of...
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Gradients of neurotransmitter receptor expression in the macaque cortex
Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization...
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Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor
Cannabis sativa has been used for improving sleep for long history. Cannabidiol (CBD) has drown much attention as a non-addictive psychoactive...
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The Role of the Serotonergic System of the Brain in the Pathogenesis of Parkinson’s Disease
AbstractThe traditional view of Parkinson’s disease (PD) relies on dopamine depletion in the striatum. However, PD is a multi-systemic disease that...
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Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
Although we understand how serotonin receptors function at the single-cell level, what role different serotonin receptors play in regulating...
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On the Disbalance and Impairment of Serotonin Heteroreceptor Complexes in the Rat Brain After MDMA and Hallucinogens Administration
The introduction of allosteric receptor–receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the CNS gives a new...
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On the Disbalance and Impairment of Serotonin Heteroreceptor Complexes in the Rat Brain After MDMA and Hallucinogens Administration
The introduction of allosteric receptor–receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the CNS gives a new...
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Generative Modelling of Cortical Receptor Distributions from Cytoarchitectonic Images in the Macaque Brain
Neurotransmitter receptor densities are relevant for understanding the molecular architecture of brain regions. Quantitative in vitro receptor...
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Electroacupuncture ameliorates learning and memory deficits via hippocampal 5-HT1A receptors and the PKA signaling pathway in rats with ischemic stroke
Hippocampal 5-HT1A receptors and the PKA signaling pathway have been implicated in learning and memory. This study aimed to investigate whether PKA...
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The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia
General anesthesia is widely used in various clinical practices due to its ability to cause loss of consciousness. However, the exact mechanism of...
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The Influence of Stress on the Expression of Brain-Derived Neurotrophic Factor (BDNF) and Its Precursor proBDNF in Mice with Different Sensitivity of Serotonin 5-HT1A Receptors
Abstract —Recently, it has become apparent that the interaction between the serotonin (5-HT) system and the brain-derived neurotrophic factor (BDNF)...
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An ontogenic study of receptor mechanisms by which acute administration of low-doses of methamphetamine suppresses DOI-induced 5-HT2A-receptor mediated head-twitch response in mice
BackgroundMethamphetamine (MA) is a non-selective monoamine releaser and thus releases serotonin (5-HT), norepinephrine (NE) and dopamine (DA) from...
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Neuroprotective and Neurite Outgrowth Stimulating Effects of New Low-Basicity 5-HT7 Receptor Agonists: In Vitro Study in Human Neuroblastoma SH-SY5Y Cells
There is some evidence that the serotonin receptor subtype 7 (5-HT 7 ) could be new therapeutic target for neuroprotection. The aim of this study was...
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Integrated network pharmacology analysis and experimental validation to investigate the mechanism of Flavan-3-ols and aromatic resins in depression
The present investigation delved into the pharmacological mechanisms underlying the management of depression through Flavan-3-ols and Aromatic Resins,...
