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5-HT 2A and 5-HT 2C receptor antagonism differentially modulate reinforcement learning and cognitive flexibility: behavioural and computational evidence
RationaleCognitive flexibility, the ability to adapt behaviour in response to a changing environment, is disrupted in several neuropsychiatric...
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The role of hippocampal 5-HT1D and 5-HT1F receptors on learning and memory in rats
Serotonin is a neurotransmitter, which is involved in memory via its receptors. The 5-HT 1D and 5-HT 1F receptors mainly exist in the hippocampus,...
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Zacopride stimulates 5-HT4 serotonin receptors in the human atrium
Zacopride (4-amino-5-chloro-2-methoxy-N-(quinuclidin-3-yl)-benzamide) is a potent agonist in human 5-HT 4 serotonin receptors in vitro and in the...
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Mosapride stimulates human 5-HT4-serotonin receptors in the heart
Mosapride (4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl) methyl]-2-morpholinyl]-methyl] benzamide) is a potent agonist at gastrointestinal 5-HT 4 ...
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5-HT Neural System Abnormalities in PTSD Model Rats
To do translational research on illness, a suitable animal model is needed. Since the symptoms of post-traumatic stress disorder (PTSD) exist across...
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Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance test
RationaleNeuropsychiatric disorders such as depression are characterized in part by attention deficits. Attention is modulated by the serotonin...
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Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference
Social interaction among conspecifics is essential for maintaining adaptive, cooperative, and social behaviors, along with survival among mammals....
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Thalamic Nucleus Reuniens Glutamatergic Neurons Mediate Colorectal Visceral Pain in Mice via 5-HT2B Receptors
Irritable bowel syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral...
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The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia
General anesthesia is widely used in various clinical practices due to its ability to cause loss of consciousness. However, the exact mechanism of...
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Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HT1A Receptor
Cannabis sativa has been used for improving sleep for long history. Cannabidiol (CBD) has drown much attention as a non-addictive psychoactive...
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The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch
Itch is an unpleasant sensation that urges people and animals to scratch. Neuroimaging studies on itch have yielded extensive correlations with...
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Rapamycin Enhanced Sensitivity of HT-29 Cells to 5-Fluororacil by Promoting Autophagy
We studied the effect of cytostatic rapamycin on the antitumor activity of 5-fluorouracil (5-FU). To this end, HT-29 cells were treated with 5-FU, or...
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Activation of 5-HT6 Receptors in the Ventrolateral Orbital Cortex Produces Anti-Anxiodepressive Effects in a Rat Model of Neuropathic Pain
The comorbidity of anxiety and depression frequently occurs in patients with neuropathic pain. The ventrolateral orbital cortex (VLO) plays a...
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Development of a 5-HT7 receptor antibody for the rat: the good, the bad, and the ugly
Our laboratory has a vested interest in measuring the location and expression of the 5-hydroxytryptamine (5-HT, serotonin) 7 (5-HT 7 ) receptor in the...
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5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption
BackgroundThe microbiota–gut–brain axis plays an important role in the development of depression. The aim of this study was to investigate the...
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Lysergic acid diethylamide stimulates cardiac human H2 histamine and cardiac human 5-HT4-serotonin receptors
Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT 4 serotonin receptors and/or H 2 ...
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Cardiovascular effects of bufotenin on human 5-HT4 serotonin receptors in cardiac preparations of transgenic mice and in human atrial preparations
It is unclear whether bufotenin (= N,N-dimethyl-serotonin = 5-hydroxy-N,N-dimethyl-tryptamine), a hallucinogenic drug, can act on human cardiac...
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Modulation of DOM-Induced Head-Twitch Response by mGluR2 Agonist/Inverse Agonist is Associated with 5-HT2AR-Mediated Gs Signaling Pathway
Hallucinogenic 5-HT 2A receptor (5-HT 2A R) agonists-induced head-twitch response (HTR) is regulated by G s signaling pathway. Formation of heterodimers...
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Neuroprotective and Neurite Outgrowth Stimulating Effects of New Low-Basicity 5-HT7 Receptor Agonists: In Vitro Study in Human Neuroblastoma SH-SY5Y Cells
There is some evidence that the serotonin receptor subtype 7 (5-HT 7 ) could be new therapeutic target for neuroprotection. The aim of this study was...
