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Potential of Heterocyclic Compounds as EGFR-TK Inhibitors in Cancer Therapy
Over the last few decades, cancer has become deadliest diseases worldwide. Vascular Endothelial Growth Factor Receptor (VEGFR), Human Epidermal...
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Cell cycle arrest and induction of apoptosis of newly synthesized pyranoquinoline derivatives under microwave irradiation
A set of 2-amino-4-aryl-4 H -pyrano[3,2- h ]quinoline-3-carbonitrile derivatives were prepared via a one-pot, three-component condensation reaction...
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Pharmacogenomics of Alzheimer’s Disease: Novel Strategies for Drug Utilization and Development
Alzheimer’s disease (AD) is a priority health problem in developed countries with a high cost to society. Approximately 20% of direct costs are...
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Multicomponent Reactions for the Synthesis of Natural Products and Natural Product-Like Libraries
Multicomponent reactions involve at least three starting materials that are combined in a single operation and are convergent, atom-economic, and...
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Halogenated 2-amino-4H-pyrano[3,2-h]quinoline-3-carbonitriles as antitumor agents and structure–activity relationships of the 4-, 6-, and 9-positions
A series of halogenated 2-amino-4-aryl-4 H -pyrano[3,2- h ]quinoline-3-carbonitrile derivatives were prepared via interaction of 8-hydroxyquinoline,...
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New pyranoquinoline derivatives as vascular-disrupting anticancer agents
A series of new 4-aryl-pyranoquinoline derivatives with a focus on meta -nitro and meta -halophenyl derivatives were prepared and investigated for...
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Multifunctional Nanocarriers for Alzheimer’s Disease: Befriending the Barriers
Neurodegenerative diseases (NDDs) have been increasing in incidence in recent years and are now widespread worldwide. Neuronal death is defined as...
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Synthesis and antitumor activity evaluation of different 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives
A new interesting family of 2,5-dialkyloxazolopyrano[3,2- c ]quinolinone derivatives 4a-l were synthesized in good yields using a convenient and...
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P-Glycoprotein-Like Transporters in Leishmania: A Search for Reversal Agents
Until now, chemotherapy has been the main line of defense against Leishmania infections. However, drug use and abuse have resulted in the selection...
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Computational Design of Multitarget Drugs Against Alzheimer’s Disease
In the present review, the authors provide the basic background about the molecular targets implicated in the pathogenesis of Alzheimer’s disease....
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Adrenal Steroid Hormones
The classical way to evaluate hormone function is to surgically ablate the hormone-producing endocrine gland and substitute it with exogenously...
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QSAR analysis on tacrine-related acetylcholinesterase inhibitors
BackgroundThe evaluation of the clinical effects of Tacrine has shown efficacy in delaying the deterioration of the symptoms of Alzheimer's disease,...
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Synthesis, antitumor activity, and structure–activity relationship of some 4H-pyrano[3,2-h]quinoline and 7H-pyrimido[4′,5′:6,5]pyrano[3,2-h]quinoline derivatives
Several 4 H -pyrano[3,2- h ]quinoline ( 3a – d , 4a , 7a , b , 9a – c , 10a , b , 11a , b , and 13a – c ) and 7 H -pyrimido[4′,5′:6,5]pyrano[3,2- h ]quinoline derivatives ( 8a – c )...
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Adrenal Steroid Hormones
The classical way to evaluate hormone function is to surgically ablate the hormone-producing endocrine gland and substitute it with exogenously...
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Synthesis and antitumor activities of certain novel 2-amino-9-(4-halostyryl)-4H-pyrano[3,2-h]quinoline derivatives
AbstractA series of ( E ) 4 H -pyrano[3,2- h ]quinoline-3-carbonitrile ( 5a – f ) and ( E ) ethyl 4 H -pyrano[3,2- h ]quinoline-3-carboxylate ( 6a – f ) derivatives...
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DNA Damaging Drugs
The classical anti-cancer agents comprise cytotoxic compounds. Mostly, these drugs act by exerting DNA damage. In essence, there are two major...
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Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic Strategies for Drug Development
Alzheimer’s disease (AD) is a major problem of health and disability, with a relevant economic impact on our society. Despite important advances in...
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Microwave solvent-free condition synthesis and pharmacological evaluation of pyrano[3,2-c]quinolines
AbstractThe microwave-induced three-component one-pot synthesis of 2-amino-3-carbethoxy-4-phenylpyrano[3,2- c ]quinolin-5(6 H )-ones ( 4a–l ) from...
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Microwave-assisted CAN-catalyzed solvent-free synthesis of N-allyl quinolone-based pyrano[4,3-b]chromene and benzopyrano[3,2-c]chromene derivatives and their antimicrobial activity
A new series of pyrano[4,3- b ]chromene and benzopyrano[3,2- c ]chromene derivatives have been synthesized via microwave-assisted one-pot,...
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Synthesis and evaluation of in vitro antitubercular activity and antimicrobial activity of some novel 4H-chromeno[2,3-d]pyrimidine via 2-amino-4-phenyl-4H-chromene-3-carbonitriles
Novel 5-phenyl-1,5-dihydro-2 H -chromeno[2,3- d ]pyrimidine-2,4(3 H )-dithiones, 5-phenyl-3,5-dihydro-4 H -chromeno[2,3- d ]pyrimidin-4-ones,...