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Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing...
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3D Printing: Applications in Tissue Engineering, Medical Devices, and Drug Delivery
The gemstone of 3-dimensional (3D) printing shines up from the pyramid of additive manufacturing. Three-dimensional bioprinting technology has been...
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Organ-on-a-Chip: Novel In Vitro Model for Drug Discovery
In conventional drug discovery process, the attrition in clinical development as a consequence of late clinical trial failure has been very high. One...
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Harnessing non-destructive 3D pathology
High-throughput methods for slide-free three-dimensional (3D) pathological analyses of whole biopsies and surgical specimens offer the promise of...
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Multiorgans-on-a-Chip for Personalized Medicine
Microfluidic devices with regulated, dynamic microenvironments in which grown cells exhibit activities that mimic organ-level physiology are known as...
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Discovery and Development of Tumor Angiogenesis Assays
The angiogenesis process was described in its basic concepts in the works of the Scottish surgeon John Hunter and terminologically assessed in the...
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3D Bioprinting of Tissue Models with Customized Bioinks
The ordered assembly of multicellular structures mimicking native tissues has lately come into prominence for various applications of biomedicine. In...
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Harnessing the Space Environment for the Discovery and Development of New Medicines
The unique nature of microgravity encountered in space provides both an opportunity and challenge for drug discovery and development that cannot be...
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Modelling acute myeloid leukemia (AML): What’s new? A transition from the classical to the modern
Acute myeloid leukemia (AML) is a heterogeneous malignancy affecting myeloid cells in the bone marrow (BM) but can spread giving rise to impaired...
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Biofabrication Technologies in Hair Neoformation
Introduction The hair follicle (HF) is an exclusive adnexal structure with important cosmetic and physiological value, embodying stem cells that...
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Spatial multi-omics: novel tools to study the complexity of cardiovascular diseases
Spatial multi-omic studies have emerged as a promising approach to comprehensively analyze cells in tissues, enabling the joint analysis of multiple...
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Nuclear Medicine Imaging Procedures in Oncology
Nuclear medicine radionuclide imaging is a quantitative imaging modality based on radioisotope-labeled tracers which emit radiation in the form of...
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Towards the mechanism of spermatotoxicity of p-tert-butyl-alpha-methylhydrocinnamic aldehyde: inhibition of late stage ex-vivo spermatogenesis in rat seminiferous tubule cultures by para-tert-butyl- benzoic acid
Molecules metabolized to para-tert-butyl-benzoic acid (p-TBBA) affect male reproduction in rats through effects on spermatogenesis. This toxicity is...
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Innovative Strategies in Drug Discovery and Pharmacoinformatics
Drug discovery comprises all the activities involved in transforming a compound from a drug candidate to a product approved for marketable form and...
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General Aspects of Traumatic Neural Diseases and Requirements of Central Nervous System Implantable Biomaterials as Diagnostic and Therapeutic Tools
As living organisms, we have the ability to detect and respond to environmental stimuli for adaptation and survival purposes. The nervous system,...
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In Silico Models for Predicting Acute Systemic Toxicity
In this chapter, we give a brief overview of the regulatory requirements for acute systemic toxicity information in the European Union, and we review...
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Micro-engineering and nano-engineering approaches to investigate tumour ecosystems
The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour tissues are of interest to many cancer researchers....
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The evolving role of investigative toxicology in the pharmaceutical industry
For decades, preclinical toxicology was essentially a descriptive discipline in which treatment-related effects were carefully reported and used as a...
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Introduction
An interesting area of research in bioinorganic chemistry is medicinal inorganic chemistry that encompasses the utility of inorganic metal ions for...
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Blood Cytokines of the Ovarian Vein Basin in Different Stages of Pelvic Varicose Veins
We analyzed the blood concentration of pro- and anti-inflammatory cytokines in the ovarian vein basin area in women of the reproductive age with...