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Organ, Histotypic and Organotypic Culture, and Tissue Engineering
Organ, histotypic, and organotypic culture using mammalian three-dimensional (3D) cell culture technologies are the primary focus of this chapter....
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3D Bioprinting for Cancer Models
Bioprinting is a challenging and dynamic field of tissue engineering that rapidly progresses in the latest 20 years. Firstly, the bioprinting idea...
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Scaffold-based 3D cell culture models in cancer research
Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional...
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Newly developed 3D in vitro models to study tumor–immune interaction
Immunotherapy as a rapidly develo** therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology...
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Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions
Pulmonary infections have been a leading etiology of morbidity and mortality worldwide. Upper and lower respiratory tract infections have...
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Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting
Neurodegenerative diseases (NDs) are characterized by uncontrolled loss of neuronal cells leading to a progressive deterioration of brain functions....
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3D bioprinted cancer models: from basic biology to drug development
Effort invested in the development of new drugs often fails to be translated into meaningful clinical benefits for patients with cancer. The...
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A Comprehensive Literature Review on Advancements and Challenges in 3D Bioprinting of Human Organs: Ear, Skin, and Bone
The field of 3D bioprinting is rapidly emerging within the realm of regenerative medicine, offering significant potential in dealing with the issue...
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A multi-organ chip with matured tissue niches linked by vascular flow
Engineered tissues can be used to model human pathophysiology and test the efficacy and safety of drugs. Yet, to model whole-body physiology and...
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Potential of Patient-Derived Organoids and Other 3D Culture Models to Assess Immunotherapy Response in Cancer
Immunotherapy has arisen as a promising approach for treating cancer, but its use in the clinical field is still mostly limited to advanced patients....
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Applications of 3D organoids in toxicological studies: a comprehensive analysis based on bibliometrics and advances in toxicological mechanisms
A mechanism exploration is an important part of toxicological studies. However, traditional cell and animal models can no longer meet the current...
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Accuracy of patient-specific CT organ doses from Monte Carlo simulations: influence of CT-based voxel models
Monte Carlo simulations using patient CT images as input are the gold standard to perform patient-specific dosimetry. However, in standard clinical...
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Utilization of 3D printing technology in hepatopancreatobiliary surgery
The technology of three-dimensional (3D) printing emerged in the late 1970s and has since undergone considerable development to find numerous...
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3D Bioprinting of Human Hollow Organs
3D bioprinting is a rapidly evolving technique that has been found to have extensive applications in disease research, tissue engineering, and...
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Advanced 3D Visualization and 3D Printing in Radiology
Since the discovery of X-rays in 1895, medical imaging systems have played a crucial role in medicine by permitting the visualization of internal...
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3D Human Tumor Tissues Cultured in Dynamic Conditions as Alternative In Vitro Disease Models
The slow knowledge progression about cancer disease and the high drug clinical failure are mainly due to the inadequacy of the simplistic...
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Novel methodologies for host-microbe interactions and microbiome-targeted therapeutics in 3D organotypic skin models
BackgroundFollowing descriptive studies on skin microbiota in health and disease, mechanistic studies on the interplay between skin and microbes are...
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Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models
Osteosarcoma (OS) is the most common primary bone cancer in children and young adults. This type of cancer is characterized by a high mortality rate,...
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Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials
Despite the exciting properties and wide-reaching applications of nanobiomaterials (NBMs) in human health and medicine, their translation from bench...
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The importance of 3D fibre architecture in cancer and implications for biomaterial model design
The need for improved prediction of clinical response is driving the development of cancer models with enhanced physiological relevance. A new...
