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Epigenetic regulation of 15-lipoxygenase-1 expression in human chondrocytes by promoter methylation
Objective and design15-Lipoxygenase-1 (15-LOX-1) catalyzes the biosynthesis of many anti-inflammatory and immunomodulatory lipid mediators and was...
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Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females
BackgroundAcute kidney injury (AKI) due to ischemia-reperfusion (IR) is a serious and frequent complication in clinical settings, and mortality rates...
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Vitamin E Exerts Neuroprotective Effects in Pentylenetetrazole Kindling Epilepsy via Suppression of Ferroptosis
Epilepsy is one of the most common chronic neurological diseases. There is increasing evidence for ferroptosis playing an important role in the...
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Substrate metabolism during recovery from circuit resistance exercise in persons with spinal cord injury
IntroductionWhole body energy expenditure and lipid oxidation (Lox) are upregulated during and after exercise. Persons with spinal cord injury (SCI)...
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A Bifunctional Coordination Polymer for Al3+ Ion Detection and its Treatment Effect on Nonalcoholic Fatty Liver Disease by Promoting Lipoxygenases and Reducing Intrahepatic Triglyceride Content
In this study, a new Cd(II)-bearing coordination polymer with the chemical formula of {[Cd 4 (meda) 3 (dpe) 4 (H 2 O) 4 ]·(NO 3 ) 2 ·2(H 2 O)} n ( 1 , H 2 meda = 3,3′-meth...
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Pre-clinical atherosclerosis is found at post-mortem, in the brains of men with HIV
The aim of this study is to ascertain the burden of pre-clinical atherosclerotic changes in the brains of young adult males with HIV and explore the...
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Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension
Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that...
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Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Ferroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to...
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Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer
BackgroundIt is well established that hypercholesterolemia increases the risk of atherosclerosis, especially because it reduces the availability of...
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Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?
BackgroundMultiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), characterized by neuroinflammation,...
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PICH deficiency limits the progression of MYC-induced B-cell lymphoma
Plk1-interacting checkpoint helicase (PICH) is a DNA translocase involved in resolving ultrafine anaphase DNA bridges and, therefore, is important to...
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Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis
Environmental tobacco smoke (ETS) is known to cause lung inflammatory and injurious responses. Smoke exposure is associated with the pathobiology...
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Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors
Overexpression of 15-lipoxygenase-1 (15-LOX-1) enzyme has been reported in prostate tumors, and its expression levels are associated with the degree...
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Murine Alox8 versus the human ALOX15B ortholog: differences and similarities
Human arachidonate 15-lipoxygenase type B is a lipoxygenase that catalyzes the peroxidation of arachidonic acid at carbon-15. The corresponding...
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Experimental investigation and molecular simulations of quinone related compounds as COX/LOX inhibitors
Quinone-containing compounds have risen as promising anti-inflammatory targets; however, very little research has been directed to investigate their...
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Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
BackgroundAtherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular diseases (CVDs)...
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Isolation, invitro, invivo anti-inflammatory, analgesic and antioxidant potential of Habenaria plantegania Lindl
Habenaira plantaginea belong to orchid family which is native to Asia. Members of this family are commonly famous for the cure of pain and...
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A Narrative Review of the Published Pre-Clinical Evaluations: Multiple Effects of Arachidonic Acid, its Metabolic Enzymes and Metabolites in Epilepsy
Arachidonic acid (AA), an important polyunsaturated fatty acid in the brain, is hydrolyzed by a direct action of phospholipase A 2 (PLA 2 ) or through...
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Matrix stiffness affects tumor-associated macrophage functional polarization and its potential in tumor therapy
The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical transduction and biochemical signal transformation....
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Polyphenol-based targeted therapy for oral submucous fibrosis
Oral submucous fibrosis (OSF) is a chronic, progressive, and precancerous condition mainly caused by chewing areca nut. Currently, OSF therapy...
