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Identification of unique rectal cancer-specific subtypes
BackgroundExisting colorectal cancer subty** methods were generated without much consideration of potential differences in expression profiles...
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Functional proteomics of colon cancer Consensus Molecular Subtypes
BackgroundThe Colorectal Cancer Subty** Consortium established four Consensus Molecular Subtypes (CMS) in colorectal cancer: CMS1...
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Unraveling progression subtypes in people with Huntington’s disease
BackgroundHuntington’s disease (HD) is a progressive neurodegenerative disease caused by a CAG trinucleotide expansion in the huntingtin gene. The...
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Progression subtypes in Parkinson’s disease identified by a data-driven multi cohort analysis
The progression of Parkinson’s disease (PD) is heterogeneous across patients, affecting counseling and inflating the number of patients needed to...
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Clinically conserved genomic subtypes of gastric adenocarcinoma
Gastric adenocarcinoma (GAC) is a lethal disease characterized by genomic and clinical heterogeneity. By integrating 8 previously established genomic...
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Unique functional responses differentially map onto genetic subtypes of dopamine neurons
Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. Dopamine neuron...
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Clinical subtypes in patients with isolated REM sleep behaviour disorder
Patients with Parkinson’s disease (PD) show a broad heterogeneity in clinical presentation, and subtypes may already arise in prodromal disease...
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Identification of novel molecular subtypes to improve the classification framework of nasopharyngeal carcinoma
BackgroundNasopharyngeal carcinoma (NPC) treatment is largely based on a ‘one-drug-fits-all’ strategy in patients with similar pathological...
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Development, wiring and function of dopamine neuron subtypes
The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are...
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Rare subtypes of triple negative breast cancer: Current understanding and future directions
Rare subtypes of triple-negative breast cancers (TNBC) are a heterogenous group of tumors, comprising 5–10% of all TNBCs. Despite accounting for an...
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Identifying functional subtypes of IgA nephropathy based on three machine learning algorithms and WGCNA
BackgroundIgA nephropathy (IgAN) is one of the most common primary glomerulonephritis, which is a significant cause of renal failure. At present, the...
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Feature Importance Genes from Breast Cancer Subtypes Classification Employing Machine Learning
AbstractThe heterogeneous nature of breast cancer necessitates exploring its molecular subtypes for the early prognosis and treatment of cancer...
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PANoptosis subtypes predict prognosis and immune efficacy in gastric cancer
PANoptosis is a form of inflammatory programmed cell death that is regulated by the PANoptosome. This PANoptosis possesses key characteristics of...
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Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk
The analysis of longitudinal data from electronic health records (EHRs) has the potential to improve clinical diagnoses and enable personalized...
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Two distinct neuroanatomical subtypes of migraine without aura revealed by heterogeneity through discriminative analysis
The neurobiological heterogeneity in migraine is poorly studied, resulting in conflicting neuroimaging findings. This study used a newly proposed...
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Dissection of pro-tumoral macrophage subtypes and immunosuppressive cells participating in M2 polarization
Alternatively activated macrophage (M2) polarization can result in one of four subtypes based on cytokines and signaling pathways associated with...
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Novel data-driven subtypes and stages of brain atrophy in the ALS–FTD spectrum
BackgroundTDP-43 proteinopathies represent a spectrum of neurological disorders, anchored clinically on either end by amyotrophic lateral sclerosis...
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MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different...
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Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes
BackgroundProstate cancer (PC) is a heterogenous multifocal disease ranging from indolent to lethal states. For improved treatment-stratification,...
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Deciphering fatty acid biosynthesis-driven molecular subtypes in pancreatic ductal adenocarcinoma with prognostic insights
PurposePancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to its high heterogeneity and aggressiveness. Recognizing the...
