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Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy
To reduce the problems of poor solubility, high in vivo dosage requirement, and weak targeting ability of paclitaxel (PTX), a hyaluronic...
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Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment
Metastasis is one of the main reasons causing death in cancer patients. It was reported that chemotherapy might induce metastasis. In order to...
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Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF-κB pathways
目的以利用小鼠原代腹腔巨噬细胞建立了一种温和气单胞菌体外感染模型, 探究MAPK、 AKT和NF-κB信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制, 为防治温和气单胞菌造成的感染提供新的治疗靶点.
创新点首次探究了丝裂原活化蛋白激酶(mitogen-activated...
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Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment
Exosomes and long non-coding RNAs (lncRNAs) are emerging as important elements contributing to a more comprehensive understanding of cancer...
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Advances in low-frequency ultrasound combined with microbubbles in targeted tumor therapy
The development of low-frequency ultrasound imaging technology and the improvement of ultrasound contrast agent production technology mean that they...
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Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met
Verticillin A is a diketopiperazine compound which was previously isolated from Amanita flavorubescens Alk (containing parasitic fungi Hypomyces...
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MicroRNAs in tumor immunity: functional regulation in tumor-associated macrophages
Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME) and are critical for cancer initiation and...
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Role of cytoplasmic lncRNAs in regulating cancer signaling pathways
Cancer remains a serious healthcare problem despite significant improvements in early detection and treatment approaches in the past few decades....
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Roles of miRNA and IncRNA in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast cancer without effective targeted therapies, which makes its...
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Complex roles of necroptosis in cancer
Necroptosis is a tightly regulated form of necrosis that requires the activation of receptor-interacting protein (RIP) kinases RIPK1 and RIPK3, as...
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Roles of flotillins in tumors
The identification and use of molecular biomarkers have greatly improved the diagnosis and treatment of malignant tumors. However, a much deeper...
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Bile-ology: from bench to bedside
Bile acids (BAs) are originally known as detergents essential for the digestion and absorption of lipids. In recent years, extensive research has...
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Role of exosome-associated microRNA in diagnostic and therapeutic applications to metabolic disorders
Metabolic disorders are classified clinically as a complex and varied group of diseases including metabolic syndrome, obesity, and diabetes mellitus....
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The construction of siRNA plasmid targeting mouse HIF-1α and in vitro study of its inhibition effect
ObjectiveTo construct effective RNA-interference plasmids targeting mouse HIF-1α gene and testify their effects and specificities in interfering...