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Highly sensitive serological approaches for Pepino mosaic virus detection
Pepino mosaic virus (PepMV) causes severe disease in tomato and other Solanaceous crops around globe. To effectively study and manage this viral...
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Efficient genetic transformation and CRISPR/Cas9-mediated genome editing of watermelon assisted by genes encoding developmental regulators
目的克服西瓜遗传转化瓶颈, 建立西瓜高效遗传转化体系, 并以此为基础构建西瓜基因编辑体系, 促进西瓜功能基因组学和基因编辑育种研究。
创新点通过比较多个生长调节基因和农杆菌菌株, 选取生长调节基因 AtGRF5 和农杆菌菌株GV3101, 在西瓜中建立了高效且不依赖于基因型的转化体系,...
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Gene editing: an instrument for practical application of gene biology to plant breeding
Plant breeding is well recognized as one of the most important means to meet food security challenges caused by the ever-increasing world population....
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A near-infrared spectroscopy-based end-point determination method for the blending process of Dahuang soda tablets
ObjectivesThis study is aimed to explore the blending process of Dahuang soda tablets. These are composed of two active pharmaceutical ingredients...
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Advances in studies on ion transporters involved in salt tolerance and breeding crop cultivars with high salt tolerance
Soil salinity is a global major abiotic stress threatening crop productivity. In salty conditions, plants may suffer from osmotic, ionic, and...
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Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy
ObjectiveTo investigate the value of optic disc retinal nerve fiber layer (RNFL) thickness in the diagnosis of diabetic peripheral neuropathy (DPN).
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Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein
Acrolein, known as one of the most common reactive carbonyl species, is a toxic small molecule affecting human health in daily life. This study is...
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Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF-κB pathways
目的以利用小鼠原代腹腔巨噬细胞建立了一种温和气单胞菌体外感染模型, 探究MAPK、 AKT和NF-κB信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制, 为防治温和气单胞菌造成的感染提供新的治疗靶点.
创新点首次探究了丝裂原活化蛋白激酶(mitogen-activated...
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Comparative transcriptomic analysis of vascular endothelial cells after hypoxia/re-oxygenation induction based on microarray technology
ObjectiveTo provide comprehensive data to understand mechanisms of vascular endothelial cell (VEC) response to hypoxia/re-oxygenation.
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Comprehensive genetic diagnosis of patients with Duchenne/Becker muscular dystrophy (DMD/BMD) and pathogenicity analysis of splice site variants in the DMD gene
Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are caused by mutations in the DMD gene. The aim of this study is to identify...
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On the necessity of an integrative approach to understand protein structural dynamics
Proteins are dynamic, fluctuating between multiple conformational states. Protein dynamics, spanning orders of magnitude in time and space, allow...
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Activation of anthrachamycin biosynthesis in Streptomyces chattanoogensis L10 by site-directed mutagenesis of rpoB
Genome sequencing projects revealed massive cryptic gene clusters encoding the undiscovered secondary metabolites in Streptomyces. To investigate the...
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Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy
To reduce the problems of poor solubility, high in vivo dosage requirement, and weak targeting ability of paclitaxel (PTX), a hyaluronic...