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Zearalenone disturbs the reproductive-immune axis in pigs: the role of gut microbial metabolites
BackgroundExposure to zearalenone (ZEN, a widespread Fusarium mycotoxin) causes reproductive toxicity and immunotoxicity in farm animals, and it...
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Structural Analysis of Par-4 and Crystallographic Analysis of the Regulatory Domain
Par-4 is a largely disordered 332 amino-acid proapoptotic protein with tumor suppressor activity that is part of extrinsic/death receptor-mediated...
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Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA
BackgroundThe respiratory pathogen Streptococcus pneumoniae (the pneumococcus) is a genetically diverse bacterium associated with over 101...
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Saturation genome editing maps the functional spectrum of pathogenic VHL alleles
To maximize the impact of precision medicine approaches, it is critical to identify genetic variants underlying disease and to accurately quantify...
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Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers
BackgroundPTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability....
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‘Esca**’ the X chromosome leads to increased gene expression in the male germline of Drosophila melanogaster
Genomic analyses of Drosophila species suggest that the X chromosome presents an unfavourable environment for the expression of genes in the male...
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The characterization of internal promoters in the Bacillus subtilis riboflavin biosynthesis operon
The transcription start sites of two internal promoters, the P2 and P3 promoters, in the Bacillus subtilis riboflavin biosynthesis operon were...
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A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells
BackgroundMolecular changes in multiple biological processes contribute to the development of chronic neurodegeneration such as late onset...
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Evolutionary genetics of MHC class II beta genes in the brown hare, Lepus europaeus
The genes of the major histocompatibility complex (MHC) are attractive candidates for investigating the link between adaptive variation and...
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Genome-Wide Transposon Mutagenesis in Saccharomyces cerevisiae and Candida albicans
Transposon mutagenesis is an effective method for generating large sets of random mutations in target DNA, with applicability toward numerous types...
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Polymorphism and signatures of selection in the multimammate rat DQB gene
In order to test if DQB is a good candidate marker to investigate the relationship between major histocompatibility complex genes and pathogens in...
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Multifunctional regulatory mutation in Bacillus subtilis flavinogenesis system
Among Bacillus subtilis riboflavin-resistant mutants we identified one, which differed from other regulatory mutants by overproduction of riboflavin...
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A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation
BackgroundAlterations in multiple cellular pathways contribute to the development of chronic neurodegeneration such as a sporadic Alzheimer's disease...
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Mitochondrial DNA mutations in human disease
The human mitochondrial genome is extremely small compared with the nuclear genome, and mitochondrial genetics presents unique clinical and...
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Brief Communication: Role of Nuclear Background and in vivo Environment in Variable Segregation Behavior of the Aging-Dependent T414G Mutation at Critical Control Site for Human Fibroblast mtDNA Replication
Previous work had shown a large accumulation (up to 50% of mtDNA) of a noninherited T414G transversion at a critical control site for mtDNA...
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Fractionation of DNA from Bacillus subtilis and its transforming activity for various markers
The physical, chemical, and functional heterogeneity of tranforming DNA was studied by preparative fractionation techniques providing resolution with...