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Hormone Relaxin as Biomarker for Bone Health and Disease
Bone homeostasis is maintained by fine-tuning of the dynamic balance between bone resorption via osteoclasts and bone formation via osteoblasts. Bone...
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Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss
Sphingosine-1-phosphate (S1P) signaling influences bone metabolism, but its therapeutic potential in bone disorders has remained unexplored. We show...
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Biochemical Markers of Bone Turnover
The use of clinically relevant biomarkers provides an important noninvasive, sensitive, rapid, and real-time tool to monitor bone activity at the...
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Effect of Statins on Bone Turnover Markers
The link between statins, the most prescribed drugs worldwide, and the bone remodeling process have been recently suggested. Thus, there is growing...
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Chitinases as Biomarkers in Bone Studies
Despite the hardness and strength characteristic, the bone is not a static tissue, but is constantly changing and constantly repairing. This process...
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Concurrent antitumor and bone-protective effects of everolimus in osteotropic breast cancer
BackgroundThe mammalian target of rapamycin inhibitor everolimus is approved as an antitumor agent in advanced estrogen receptor-positive breast...
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Hormone Relaxin as Biomarker for Bone Health and Disease
Bone homeostasis is maintained by fine-tuning of the dynamic balance between bone resorption via osteoclasts and bone formation via osteoblasts. Bone...
-
Effect of Statins on Bone Turnover Markers
The link between statins, the most prescribed drugs worldwide, and the bone remodeling process have been recently suggested. Thus, there is growing...
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Chitinases as Biomarkers in Bone Studies
Despite the hardness and strength characteristic, the bone is not a static tissue, but is constantly changing and constantly repairing. This process...
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Bone Biomarkers in Research and Clinical Practice
Biomarkers as tools for aiding diagnosis, for identifying patients at risk, for monitoring response to therapy and for use as surrogate end points in...
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Comparison of the effects of cholecalciferol and calcitriol on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency
Aim:To compare the effects of cholecalciferol (800 IU/d) and calcitriol (0.25 μg/d) on calcium metabolism and bone turnover in Chinese postmenopausal...
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Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments
BackgroundFragments of collagen type I containing the epitope AHDGGR (CTX) are generated during bone resorption. The aspartyl-glycine (DG) site...
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Markers of bone turnover for the management of patients with bone metastases from prostate cancer
Although increased bone formation is a prominent feature of patients with osteosclerotic metastases from prostate cancer, there is also some evidence...