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Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)
Synaptic vesicle glycoprotein-2 (SV2) is a family of proteins consisting of SV2A, SV2B, and SV2C. This protein family has attracted attention in...
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Early administration of umbilical cord blood cells following brief high tidal volume ventilation in preterm sheep: a cautionary tale
BackgroundUmbilical cord blood (UCB) cells are a promising treatment for preterm brain injury. Access to allogeneic sources of UCB cells offer the...
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Preoperative serum bilirubin is an independent prognostic factor for curatively resected esophageal squamous cell carcinoma
PurposeThis study examines prognostic value of preoperative serum bilirubin, including unconjugated bilirubin (UCB), conjugated bilirubin (CB), and...
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LncRNA MIR4435-2HG drives cancer progression by modulating cell cycle regulators and mTOR signaling in stroma-enriched subtypes of urothelial carcinoma of the bladder
BackgroundThe risk for recurrence and metastasis after treatment for urothelial carcinoma of the bladder (UCB) is high. Therefore, identifying...
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Synaptic loss and its association with symptom severity in Parkinson’s disease
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments....
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ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma
Metastasis is the greatest clinical challenge for UTUCs, which may have distinct molecular and cellular characteristics from earlier cancers. Herein,...
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A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease
BackgroundEffective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence...
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Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells
The functional impact and cellular context of mosaic structural variants (mSVs) in normal tissues is understudied. Utilizing Strand-seq, we sequenced...
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Microglial Priming in Bilirubin-Induced Neurotoxicity
Neuroinflammation is a major contributor to bilirubin-induced neurotoxicity, which results in severe neurological deficits. Microglia are the primary...
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Mild or Moderate COVID-19 during Pregnancy Does Not Affect the Content of CD34+ Hematopoietic Stem Cells in Umbilical Cord Blood of Newborns
The study included umbilical cord blood samples ( n =64) intended for cryogenic storage of hematopoietic stem cells and obtained from patients with a...
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Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis
Nonimmune cells can have immunomodulatory roles that contribute to healthy development. However, the molecular and cellular mechanisms underlying the...
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Positron Emission Tomography (PET) Imaging Biomarkers in Huntington’s Disease
Huntington’s disease (HD) is a rare, autosomal, and dominantly inherited neurodegenerative disease characterized by aggregation of mutated Huntingtin...
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Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1
Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors have not yet been...
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NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse
The formation of an immunological synapse (IS) is essential for natural killer (NK) cells to eliminate target cells. Despite an advanced...
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PET Biomarkers in Psychiatry
Positron-emission tomography (PET) is an important tool that allows us to see in vivo biochemical processes in the brain. PET imaging studies in...
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The mechanisms of exosomes in diabetic foot ulcers healing: a detailed review
As time goes by, the morbidity of diabetes mellitus continues to rise, and the economic burden of diabetic foot ulcers as a common and serious...
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A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia
The molecular regulation of human hematopoietic stem cell (HSC) maintenance is therapeutically important, but limitations in experimental systems and...
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Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer’s disease
BackgroundPrevious studies have demonstrated that early intervention was the best plan to inhibit the progression of Alzheimer’s disease (AD), which...
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Effect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function
The use of CD34 + cell-based therapies has largely been focused on haematological conditions. However, there is increasing evidence that umbilical...
