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Longitudinal positron emission tomography and postmortem analysis reveals widespread neuroinflammation in SARS-CoV-2 infected rhesus macaques
BackgroundCoronavirus disease 2019 (COVID-19) patients initially develop respiratory symptoms, but they may also suffer from neurological symptoms....
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In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET
BackgroundOver the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of...
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Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study
BackgroundAbnormal activation of immune system is an important pathogenesis of Parkinson’s disease, but the relationship between peripheral...
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Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain
BackgroundNeuroinflammation is an underlying pathology of all neurological conditions, the understanding of which is still being comprehended. A...
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Molecular Imaging of Neuroinflammation in Alzheimer’s Disease and Mild Cognitive Impairment
Alzheimer’s disease (AD) is the most prevalent neurocognitive disorder. Due to the ineffectiveness of treatments targeting the amyloid cascade,...
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Neuroinflammation and Immune Dysfunction in the Mechanisms of Development of Parkinson’s Disease
Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder characterized by the death of dopamine neurons, aggregation of...
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Molecular PET Imaging in Alzheimer’s Disease
PurposeThe complexities of pathological changes in Alzheimer’s disease (AD) and their relationships with associated risk factors and clinical...
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Inflammation, Obsessive-Compulsive Disorder, and Related Disorders
Initial reports supporting the possibility of inflammation in the brain in obsessive-compulsive disorder (OCD) evolved from the models of Sydenham’s...
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Biphasic Role of Microglia in Healthy and Diseased Brain
Microglia play a very important role in brain development, CNS homeostasis, and response to brain injury and in recovery from neuronal damage. These...
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Clinical evaluation of neuroinflammation in child-onset focal epilepsy: a translocator protein PET study
BackgroundNeuroinflammation is associated with various chronic neurological diseases, including epilepsy; however, neuroimaging approaches for...
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Positron Emission Tomography After Ischemic Brain Injury: Current Challenges and Future Developments
Positron emission tomography (PET) is widely used in clinical and animal studies, along with the development of diverse tracers. The biochemical...
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Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study
BackgroundMicroglial cells are activated in response to changes in brain homeostasis during aging, dementia, and stroke. Type 2 endocannabinoid...
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Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of motor neurons. As with all major neurodegenerative disorders,...
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Microstructural brain abnormalities in HIV+ individuals with or without chronic marijuana use
ObjectiveCognitive deficits and microstructural brain abnormalities are well documented in HIV-positive individuals (HIV+). This study evaluated...
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In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study
BackgroundMagnetic resonance imaging (MRI)-guided pulsed focused ultrasound combined with the infusion of microbubbles (pFUS+MB) induces transient...
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Countering Zika Virus: The USAMRIID Response
The United States Army Medical Research Institute of Infectious Diseases (USAMRIID) possesses an array of expertise in diverse capabilities for the...
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Lack of neuroinflammation in the HIV-1 transgenic rat: an [18F]-DPA714 PET imaging study
BackgroundHIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive...
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