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Photoreaction products of extract from the fruiting bodies of Polyozellus multiplex
Photochemical reactions are powerful tools for synthesizing organic molecules. The input of energy provided by light offers a means to produce...
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DNA damage mediated by UV radiation and relative repair mechanisms in mammals
Ultraviolet (UV) radiation is one of the major environmental pathogenic factors for mammals and has been identified as a carcinogen for initiating...
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Investigating the Use of Coumarin Derivatives as Lasers
A benzene ring and a lactone ring combine to form the chemical coumarin. Dye lasers have made significant advances in laser technology. The coumarin...
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The Conversion and Degradation of Sulphaguanidine under UV and Electron Beam Irradiation Using Fluorescence
The work presents a spectral-luminescent study of the sulfaguanidine transformation in water under a pulsed e-beam and UV irradiation of an UVb-04...
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Authentication of Covid-19 Vaccines Using Synchronous Fluorescence Spectroscopy
The present study demonstrates the potential of synchronous fluorescence spectroscopy and multivariate data analysis for authentication of COVID-19...
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Measuring UV Photoproduct Repair in Isolated Telomeres and Bulk Genomic DNA
Telomere repeats at chromosomal ends are essential for genome stability and sustained cellular proliferation but are susceptible to DNA damage....
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Photoprotective Therapeutics: Recent Trends and Future Applications
Electromagnetic spectrum consists of various rays—infrared, ionizing, x-ray and ultraviolet radiation. Ozone coverings act as effective protective...
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Detection of UV-Induced Thymine Dimers
Ultraviolet rays induce interstrand and intrastrand DNA cross-links, usually thymine–thymine cyclobutane dimer (T–T) and thymine–thymine...
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Ruthenium Nitrosyl Complexes: Photoinduced Delivery of NO to Different Biological Targets
Nitric oxide (NO) molecule participates in various biological events such as vasodilation, neurotransmission, antioxidant, and immune responses. In...
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Phytochromes and Cyanobacteriochromes: Photoreceptor Molecules Incorporating a Linear Tetrapyrrole Chromophore
In this chapter, we summarize the molecular mechanisms of the linear tetrapyrrole-binding photoreceptors, phytochromes, and cyanobacteriochromes. We...
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Aryl Hydrocarbon Receptor in Glia Cells: A Plausible Glutamatergic Neurotransmission Orchestrator
Glutamate is the major excitatory amino acid in the vertebrate brain. Glutamatergic signaling is involved in most of the central nervous system...
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The Genetic Basis of Cancer
Cancer is a genetic disease caused by mutations that arise in our genomic DNA. Specific types of mutations drive a lengthy evolutionary process that...
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UVR Induced Vitamin D Synthesis and Skin Cancer
Ultraviolet radiation (UVR) is the major etiological agent for the development of skin cancers. UVR causes DNA damage and genetic mutations, which...
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The epigenetic DNA modification 5-carboxylcytosine promotes high levels of cyclobutane pyrimidine dimer formation upon UVB irradiation
In mammals, DNA methyltransferases create 5-methylcytosines (5mC) predominantly at CpG dinucleotides. 5mC oxidases convert 5mC in three consecutive...
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Microdialysis of Voriconazole and its N-Oxide Metabolite: Amalgamating Knowledge of Distribution and Metabolism Processes in Humans
PurposeVoriconazole is an essential antifungal drug whose complex pharmacokinetics with high interindividual variability impedes effective and safe...
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Phenylalanine Photoinduced Fluorescence and Characterization of the Photoproducts by LC-MS
Phenylalanine (Phe) is a direct precursor of tyrosine and several neurotransmitters. The accumulation of Phe in the brain generates serious and not...
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Cancer incidence and mortality and risk factors in member countries of the " Belt and Road " initiative
BackgroundAt present, “Belt and Road” (“B&R”) member states (accounting for about 61.78% of the world’s population) face different types of cancer...
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Methods and applications of genome-wide profiling of DNA damage and rare mutations
DNA damage is a threat to genome integrity and can be a cause of many human diseases, owing to either changes in the chemical structure of DNA or...
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Strategies of chemolithoautotrophs adapting to high temperature and extremely acidic conditions in a shallow hydrothermal ecosystem
BackgroundActive hydrothermal vents create extreme conditions characterized by high temperatures, low pH levels, and elevated concentrations of heavy...
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DNA Damage and DNA Repair
This chapter describes in more detail the various kinds of DNA damage that can cause mutations and chromosomal alterations as well as the...