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Identification and characterisation of the haemozoin of Haemonchus contortus
BackgroundMost haematophagous organisms constantly suck the host’s haemoglobin, which produces toxic free haem. This toxic haem aggregation into the...
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The ability of Interleukin–10 to negate haemozoin-related pro-inflammatory effects has the potential to restore impaired macrophage function associated with malaria infection
BackgroundAlthough pro-inflammatory cytokines are involved in the clearance of Plasmodium falciparum during the early stages of the infection,...
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Evaluation of a haemozoin-based rapid diagnostic test for diagnosis of imported malaria during the phase of prevention of reestablishment in Sri Lanka
BackgroundSri Lanka, an island nation, has eliminated endemic malaria transmission. Maintaining elimination in the continued presence of vectors...
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2D-quantitative structure–activity relationships model using PLS method for anti-malarial activities of anti-haemozoin compounds
BackgroundEmergence of cross-resistance to current anti-malarial drugs has led to an urgent need for identification of potential compounds with novel...
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Performance of a sensitive haemozoin‐based malaria diagnostic test validated for vivax malaria diagnosis in Brazilian Amazon
BackgroundVivax malaria diagnosis remains a challenge in malaria elimination, with current point of care rapid diagnostic tests (RDT) missing many...
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Correlation between anti-malarial and anti-haemozoin activities of anti-malarial compounds
BackgroundDespite noticeable improvement in anti-malarial treatment, rapid growth of resistant malaria strains points out the need for continuous...
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Interplay between Plasmodium falciparum haemozoin and l-arginine: implication for nitric oxide production
BackgroundPlasmodium falciparum haemozoin, a detoxification product of digested haemoglobin from infected erythrocytes, is released into the...
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Unresolved haemosporidia of the Australian skink, Egernia stokesii
The Australian skink Egernia stokesii had been recognised as a host of two species of Plasmodium , Plasmodium mackerrasae and P. circularis ;...
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Course of Plasmodium infection studied using 2D-COS on human erythrocytes
BackgroundThe threat of malaria is still present in the world. Recognizing the type of parasite is important in determining a treatment plan. The...
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Plasmodium falciparum alters the trophoblastic barrier and stroma villi organization of human placental villi explants
BackgroundThe sequestration of Plasmodium falciparum infected erythrocytes in the placenta, and the resulting inflammatory response affects maternal...
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Apoptotic changes and aquaporin-1 expression in the choroid plexus of cerebral malaria patients
BackgroundCerebral malaria (CM) is associated with sequestration of parasitized red blood cells (PRBCs) in the capillaries. Often, the association of...
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Detection and quantification of Plasmodium falciparum in human blood by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a proof of concept study
BackgroundMatrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) has revolutionized identification of bacteria and...
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Disruption of Plasmodium falciparum histidine-rich protein 2 may affect haem metabolism in the blood stage
BackgroundHaem is a key metabolic factor in the life cycle of the malaria parasite. In the blood stage, the parasite acquires host haemoglobin to...
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In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes
BackgroundMalaria extensively leads to mortality and morbidity in endemic regions, and the emergence of drug resistant parasites is alarming. Plant...
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Haematological parameters and their correlation with the degree of malaria parasitaemia among outpatients attending a polyclinic
BackgroundMalaria is a parasitic disease caused by various species of the blood parasite Plasmodium; of all the parasitic diseases, malaria has the...
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Triple artemisinin-based combination therapy (TACT): advancing malaria control and eradication efforts
This paper examines the far-reaching implications of Triple Artemisinin-Based Combination Therapy (TACT) in the global battle against malaria....
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Piperine Enhances Antimalarial Activity of Methyl Gallate and Palmatine Combination
PurposeArtemisinin combination therapies, the first-line antimalarials in Nigeria, have reportedly suffered multiple failures in malaria treatment,...
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Factors influencing phagocytosis of malaria parasites: the story so far
There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to...
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CD4+ICOS+Foxp3+: a sub-population of regulatory T cells contribute to malaria pathogenesis
BackgroundRegulatory T cells are known to play a key role to counter balance the protective immune response and immune mediated pathology. However,...
