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Epigenetics in Male Reproduction: A Practical Introduction to the Informatics of Next Generation Sequencing
At fertilization, the male germ cell conveys a richly layered genetic landscape consisting of both DNA and its associated epigenetic information. A...
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CDK19 is disrupted in a female patient with bilateral congenital retinal folds, microcephaly and mild mental retardation
Microcephaly, mental retardation and congenital retinal folds along with other systemic features have previously been reported as a separate clinical...
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The genome of the cucumber, Cucumis sativus L.
Cucumber is an economically important crop as well as a model system for sex determination studies and plant vascular biology. Here we report the...
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Identifying repeats and transposable elements in sequenced genomes: how to find your way through the dense forest of programs
The production of genome sequences has led to another important advance in their annotation, which is closely linked to the exact determination of...
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Erythropoiesis: an overview
Red blood cell production in vertebrates is dynamic and tightly regulated with losses due to senescence or bleeding in normal individuals being...
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Evidence of Sibling Species in the Brown Planthopper Complex (Nilaparvata lugens) Detected from Short and Long Primer Random Amplified Polymorphic DNA Fingerprints
The inheritance of 31 amplicons from short and long primer RAPD was tested for segregating ratios in two families of the brown planthopper, Nilaparvata lugens,...
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Enhancement of single motor unit inhibitory responses to transcranial magnetic stimulation in amyotrophic lateral sclerosis
In healthy human subjects, transcranial magnetic stimulation (TMS) applied to the motor cortex induces concurrent inhibitory and excitatory effects...
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Electronic Prescribing
Prescription of antibiotic treatment is complex. While most patients with fever do not require antibiotic treatment, early administration of...
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LitMiner: integration of library services within a bio-informatics application
BackgroundThis paper examines how the adoption of a subject-specific library service has changed the way in which its users interact with a digital...
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Psychotropic and Neurotropic Activity
The effects of drugs on the central and peripheral nervous systems can be easily recognized in normal animals. This does not necessarily mean that...
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Improving the Therapeutic Performance of a Medical Bayesian Network Using Noisy Threshold Models
Treatment management in critically ill patients needs to be efficient, as delay in treatment may give rise to deterioration in the patient’s...
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Extracellular matrix distribution and islet morphology in the early postnatal pancreas: anomalies in the non-obese diabetic mouse
Previously, we reported elevated numbers of macrophages in the pancreas of NOD mice, a spontaneous animal model for T1D, during the early postnatal...
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Biomarkers of Alzheimer disease in plasma
Plasma and serum biochemical markers proposed for Alzheimer disease (AD) are based on pathophysiologic processes such as amyloid plaque formation...
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Specific visualization of precipitated cerium by energy-filtered transmission electron microscopy for detection of alkaline phosphatase in immunoenzymatic double labeling of tyrosine hydroxylase and serotonin in the rat olfactory bulb
To understand in detail the functional morphology of neuronal circuits it is important to identify at the ultrastructural level the incoming axon,...
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Localization of epidermal-type fatty acid binding protein in the thymic epithelial cells of mice
The immunoreactivity for epidermal-type fatty acid binding protein of epidermis type (E-FABP) was selectively localized in the epithelial cells of...
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Real-Time Detection of Minimal Residual Disease by Amplifying Immunoglobulin Genes in Acute Lymphoblastic Leukemia on the LightCycler
Acute lymphoblastic leukemia (ALL) is the most frequent malignancy among children. ALL is characterized as the malignant transformation and clonal...