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Ethyl acrylate: influence of sex or atopy on perceptual ratings and eye blink frequency
Occupational exposure limits (OELs) are derived for protection from health hazards, assuming that exposed subjects are healthy adult workers. Whether...
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Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming
Hyperglycemia has been shown to modulate the immune response of peripheral immune cells and organs, but the impact of hyperglycemia on...
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Systematic characterization of a non-transgenic Aβ1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice
BackgroundThe amyloid- β (A β ) cascade is one of the most studied theories linked to AD. In multiple models, A β accumulation and dyshomeostasis have...
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Visual–auditory interactions on explicit and implicit information processing
Interactions among sensory information are important for generating a coherent percept of the external world. Facilitation and inhibition effects in...
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Tetramethylpyrazine Attenuates Cognitive Impairment Via Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis in Type 2 Diabetic Rats
Cognitive dysfunction is an important complication observed in type 2 diabetes mellitus (T2DM) patients. Tetramethylpyrazine (TMP) is known to...
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Memory Storage in Distributed Engram Cell Ensembles
One of the most fascinating aspects of the brain is its ability to acquire new information from experience and retain it over time as memory. The... -
Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials
Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of a new pharmacological...
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TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair
BackgroundThe repair of white matter injury is of significant importance for functional recovery after ischemic stroke, and the up-regulation of...
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Kapβ2 Inhibits Perioperative Neurocognitive Disorders in Rats with Mild Cognitive Impairment by Reversing the Nuclear-Cytoplasmic Mislocalization of hnRNPA2/B1
Harmful stimuli trigger mutations lead to uncontrolled accumulation of hnRNPA2/B1 in the cytoplasm, exacerbating neuronal damage. Kapβ2 mediates the...
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Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome
Rett syndrome (RTT) is a neurodevelopmental disorder that is characterized by developmental regression, loss of communicative ability, stereotyped...
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Sensory Systems of the African Naked Mole-Rat
Naked mole-rats share some sensory characteristics with other subterraneans, including lack of object vision, retention of the ability to entrain... -
Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer’s disease mice
BackgroundA growing body of epidemiological literature indicates that particulate matter (PM) air pollution exposure is associated with elevated...
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Fluorescent Light Opening New Horizons
In this final Chapter we try to evaluate the most rapidly progressing application areas of fluorescence sensing technologies and to make prognosis... -
Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3
RationaleThe voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is...
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Sex Differences in Social Cognition
In this review we explore the sex differences underlying various types of social cognition. Particular focus will be placed on the behaviors of... -
BDNF Augmentation Using Riluzole Reverses Doxorubicin-Induced Decline in Cognitive Function and Neurogenesis
Cancer-related cognitive impairment (CRCI) considerably affects the quality of life of millions of cancer survivors. Brain-derived neurotrophic...
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Integrated Transcriptomics and Network Analysis Identified Altered Neural Mechanisms in Frontal Aging Brain-Associated Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease. The late stage of AD typically develops after 60 years of age and AD...
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Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex
Olfaction is one of the major sensory modalities that regulates food consumption and is in turn regulated by the feeding state. Given that the...
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Hippocampal Engrams and Contextual Memory
Memories are not formed in a vacuum and often include rich details about the time and place in which events occur. Contextual stimuli promote the... -
The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story
Olfactory marker protein (OMP) was first described as a protein expressed in olfactory receptor neurons (ORNs) in the nasal cavity. In particular,...