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Myosins in Cytokinesis
Nearly five decades of research have established myosin as the main motor responsible for cytokinesis in organisms on the branch of the phylogenetic...
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The Chemoprevention of Hereditary Diffuse Gastric Cancer
Mutations in the CDH1 gene are the genetic hallmark of hereditary diffuse gastric cancer (HDGC), a cancer syndrome characterised by high rates of...
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Autophagosome Trafficking
Autophagy is a major intracellular degradation/recycling system that ubiquitously exists in eukaryotic cells. Autophagy contributes to the turnover...
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The effects of 808-nm near-infrared laser light irradiation on actin cytoskeleton reorganization in bone marrow mesenchymal stem cells
Tailoring the cell organelles and thus changing cell homeostatic behavior has permitted the discovery of fascinating metabolic features enabling...
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Expanding Role of Marine Natural Compounds in Immunomodulation: Challenges and Future Perspectives
Marine flora is a source of novel compounds with biological activities. Over the years, thousands of marine organisms evolved in the habitat where...
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Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm
Night shift workers with disordered rhythmic mechanical loading are more prone to intervertebral disc degeneration (IDD). Our results showed that...
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Detection of porcine cytomegalovirus, a roseolovirus, in pig ovaries and follicular fluid: implications for somatic cells nuclear transfer, cloning and xenotransplantation
BackgroundPorcine cytomegalovirus (PCMV) is a porcine roseolovirus (PCMV/PRV) which is widely distributed in pigs. Transmission of PCMV/PRV in...
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Functional importance of glucose transporters and chromatin epigenetic factors in Glioblastoma Multiforme (GBM): possible therapeutics
Glioblastoma Multiforme (GBM) is an aggressive brain cancer affecting glial cells and is chemo- and radio-resistant. Glucose is considered the most...
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High doses of tyramine stimulate glucose transport in human fat cells
Among the dietary amines present in foods and beverages, tyramine has been widely studied since its excessive ingestion can cause catecholamine...
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Toxicity Assessment of Nanoparticle
The extensive applications of nanoparticles due to their unique physicochemical and biological properties have resulted in a surge in production and...
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Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome attributed to germline CDH1 mutations that carries a high risk for...
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Hepatitis E Virus Life Cycle
Hepatitis E virus (HEV) infects over 20 million people worldwide per year, leading to 30,000–40,000 deaths. In most cases HEV infection in a...
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ADAMTS1 Is Differentially Expressed in Human Lymphocytes with Various Frequencies of Endogenous γH2AX Foci and Radiation-Induced Micronuclei
AbstractThe level of spontaneous and radiation-induced DNA damage varies depending on genetic and environmental factors in human somatic cells. This...
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The MRTF-A/miR-155/SOX1 pathway mediates gastric cancer migration and invasion
BackgroundGastric cancer (GC) is the leading cause of death worldwide and is closely related to metastasis. MRTF-A is one of the most...
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The Length of Telomeres and the Baseline Level of Cytogenetic Damage in Leukocytes of Lung Cancer Patients
AbstractDespite the great efforts of basic and clinical research on lung cancer (LC), the prevention and treatment of this type of cancer show still...
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Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue
Targeting the delivery of therapeutics specifically to diseased tissue enhances their efficacy and decreases their side effects. Here we show that...
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Homocysteine May Decrease Glucose Uptake and Alter the Akt/GSK3β/GLUT1 Signaling Pathway in Hippocampal Slices: Neuroprotective Effects of Rivastigmine and Ibuprofen
Homocysteine (Hcy) is a risk factor for neurodegenerative diseases, such as Alzheimer’s Disease, and is related to cellular and tissue damage. In the...
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Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties
Despite the prevalence of large (>5 cm 2 ) articular cartilage defects involving underlying bone, current tissue-engineered therapies only address...
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Carbon nanotube filler enhances incinerated thermoplastics-induced cytotoxicity and metabolic disruption in vitro
BackgroundEngineered nanomaterials are increasingly being incorporated into synthetic materials as fillers and additives. The potential pathological...
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Targeting the cytoskeleton against metastatic dissemination
Cancer is a pathology characterized by a loss or a perturbation of a number of typical features of normal cell behaviour. Indeed, the acquisition of...
