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Ion channels and transporters in adipose-derived stem cells
Adipose tissue-derived mesenchymal stem cells (ADSCs) can be expanded in vitro and differentiated into numerous specialized cell types because of...
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The phospholipase C inhibitor U73122 is a potent agonist of the polymodal transient receptor potential ankyrin type 1 (TRPA1) receptor channel
The aminosteroid U73122 is frequently used as a phospholipase C (PLC) inhibitor and as such was used to investigate PLC-dependent activation and...
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Ethanol’s Effects on Transient Receptor Potential Channel Expression in Brain Microvascular Endothelial Cells
Ethanol (EtOH), the main ingredient in alcoholic beverages, is well known for its behavioral, physiological, and immunosuppressive effects. There is...
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Ion Channels and Intracellular Calcium Signalling in Corpus Cavernosum
The corpus cavernosum smooth muscle is important for both erection of the penis and for maintaining penile flaccidity. Most of the time, the smooth...
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Porcine FcεRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction
Porcine reproductive and respiratory syndrome virus (PRRSV) shows characteristic antibody-dependent enhancement (ADE) of infection and causes porcine...
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Stimulus-Secretion Coupling in Beta-Cells: From Basic to Bedside
Insulin secretion in humans is usually induced by mixed meals, which upon ingestion, increase the plasma concentration of glucose, fatty acids, amino...
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Molecular Basis and Regulation of Store-Operated Calcium Entry
Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism for Ca2+ influx in mammalian cells with important physiological implications. Since the...
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Identifying novel biomarkers of the pediatric influenza infection by weighted co-expression network analysis
BackgroundDespite the high yearly prevalence of Influenza, the pathogenesis mechanism and involved genes have not been fully known. Finding the...
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The Role of H2S in the Gastrointestinal Tract and Microbiota
The pathways and mechanisms of the production of H2S in the gastrointestinal tract are briefly described, including endogenous H2S produced by the...
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This was the year that was: brain barriers and brain fluid research in 2019
This editorial highlights advances in brain barrier and brain fluid research published in 2019, as well as addressing current controversies and...
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TRPM3_miR-204: a complex locus for eye development and disease
First discovered in a light-sensitive retinal mutant of Drosophila , the transient receptor potential (TRP) superfamily of non-selective cation...
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Membrane Transporters and Channels in Melanoma
Recent research has revealed that ion channels and transporters can be important players in tumor development, progression, and therapy resistance in...
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Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients
BackgroundChronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system...
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Targeting receptor complexes: a new dimension in drug discovery
Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled receptors, has directly enabled the discovery of most drugs...
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Cellular and Ionic Mechanisms of Arterial Vasomotion
Rhythmical contractility of blood vessels was first observed in bat wing veins by Jones (Philos Trans R Soc Lond 1852:142, 131–136), and subsequently...
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CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity
CFTR, a chloride channel and ion channel regulator studied mostly in epithelial cells, has been reported to participate in immune regulation and...
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Orai Channels
The highly calcium-selective ion channels formed by the Orai proteins represent a principal route for the agonist-induced entry of extracellular...
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Matrix Metalloproteinases in Acute Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) accounts for 10–30% of all strokes and affects more than one million people every year worldwide, and it...
