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From genetics to the clinic: a translational perspective on follicular lymphoma
Follicular lymphoma (FL) is the most frequent indolent B cell lymphoma and is still considered to be incurable. In recent years, whole-exome...
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Methods for High-throughput Drug Combination Screening and Synergy Scoring
Gene products or pathways that are aberrantly activated in cancer but not in normal tissue hold great promises for being effective and safe... -
Lapatinib resistance in HER2+ cancers: latest findings and new concepts on molecular mechanisms
In the era of new and mostly effective molecular targeted therapies, human epidermal growth factor receptor 2 positive (HER2+) cancers are still...
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PI3K isoform-selective inhibitors: next-generation targeted cancer therapies
The pivotal roles of phosphatidylinositol 3-kinases (PI3Ks) in human cancers have inspired active development of small molecules to inhibit these...
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Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms
Myeloproliferative neoplasms (MPN) are a diverse group of chronic hematological disorders that involve unregulated clonal proliferation of white...