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Machine Learning in Plant Disease Research
Biotic agents including virus, viroids, fungi, bacteria, mollicutes, protozoa, and nematodes and adverse environmental conditions can affect the...
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Estimation of time to progression and post progression survival using joint modeling of summary level OS and PFS data with an ordinary differential equation model
Summary measures such as progression-free survival (PFS) and overall survival (OS) are commonly reported in literature for oncology trials, while...
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Marker-assisted introgression of genes into rye translocation leads to the improvement in bread making quality of wheat (Triticum aestivum L.)
Introgression of genes from related species can be a powerful way to genetically improve crop yields, but selection for one trait can come at the...
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HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC
BackgroundImmune checkpoint blockade (ICB) only works well for a certain subset of patients with non-small cell lung cancer (NSCLC). Therefore,...
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Precision public health in the era of genomics and big data
Precision public health (PPH) considers the interplay between genetics, lifestyle and the environment to improve disease prevention, diagnosis and...
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Potential distribution of Leptotrombidium scutellare in Yunnan and Sichuan Provinces, China, and its association with mite-borne disease transmission
BackgroundLeptotrombidium scutellare is one of the six main vectors of scrub typhus in China and is a putative vector of hemorrhagic fever with...
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Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus
Owing to the immunogenicity of adeno-associated viruses (AAVs), gene therapies using AAVs face considerable obstacles. Here, by leveraging ex vivo...
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Immune checkpoint inhibitor-related adverse cardiac events in patients with lung cancer: a systematic review and meta-analysis
BackgroundAlthough people are more and more aware of the cardiotoxicity caused by immune checkpoint inhibitors (ICIs) in the treatment of lung...
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Nanocomposites in Combating Antimicrobial Resistance
Extensive and improper usage of antibiotics has resulted in the outbreak of multidrug-resistant microorganisms and increasing antimicrobial...
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Proprioceptive afferents differentially contribute to effortful perception of object heaviness and length
When humans handle a tool, such as a tennis racket or hammer, for the first time, they often wield it to determine its inertial properties. The...
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Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease
AbstractAlzheimer’s disease (AD) is a progressive neurological condition that is accompanied by cognitive decline. The occurrence of AD is...
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Clinical benefit of immune checkpoint inhibitors approved by US Food and Drug Administration
BackgroundWe describe the clinical benefit of immune checkpoint inhibitors using the European Society for Medical Oncology Magnitude of Clinical...
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Medicinal Plants Used in Treatment of Bronchitis
Owing to the rapidly accelerated growth of resistance to the medications currently in use, respiratory tract infections are health concern worldwide....
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High Altitude Agro-ecosystems: Challenges and Opportunities
The high altitude agro-ecosystem is very delicate and fragile due to its topography and water scarcity. It triggers the disruption to the soil...
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Norepinephrine depletion in the brain sex-dependently modulates aspects of spatial learning and memory in female and male rats
RationaleThe contribution of norepinephrine on the different phases of spatial memory processing remains incompletely understood. To address this...
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Quercus infectoria G. Olivier (Fagaceae)
It is[aut] a native of Greece, Iran, Syria, Turkey, southwest Asia, and southern Europe. Greeks and Romans used galls for their astringent...
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Clinical therapeutic trials
The term clinical trial implies an investigation of a therapeutic intervention in the pursuit of evidence of benefit, short or sustained, and...
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Network approach in liquidomics landscape
Tissue-based biopsy is the present main tool to explore the molecular landscape of cancer, but it also has many limits to be frequently executed,...
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Ex Vivo Culture Models of Hidradenitis Suppurativa for Defining Molecular Pathogenesis and Treatment Efficacy of Novel Drugs
Hidradenitis suppurativa (HS) is a complex and debilitating inflammatory skin disease for which no effective treatment is available currently. This...
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Quercetin attenuates viral infections by interacting with target proteins and linked genes in chemicobiological models
Medicinally active compounds in the flavonoid class of phytochemicals are being studied for antiviral action against various DNA and RNA viruses....
