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Molecular Therapies for Malignant Gliomas
Due to the dismal prognosis of malignant glioma patients there is an urgent need for new innovative treatments based on a better understanding of the...
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Molecularly Targeted Therapies for Malignant Gliomas
This review critically evaluates current knowledge of molecularly targeted therapies of malignant gliomas. Various molecularly targeted single-agent...
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Current Clinical Management of Metastatic Lung Cancer
Approximately 40% of patients with non-small cell lung cancer (NSCLC) and 70% of patients with small cell lung cancer (SCLC) present with advanced,...
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Molecular targeting of Bcl-2 overcomes prostate cancer cell adaptation to XIAP gene downregulation
X-linked inhibitor of apoptosis (XIAP) is a suppressor of apoptosis that supports an increased survival and resistance to chemotherapy of human...
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Cancer is a Preventable Disease that Requires Major Lifestyle Changes
This year, more than 1 million Americans and more than 10 million people worldwide are expected to be diagnosed with cancer, a disease commonly...
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Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor
Osteosarcoma is major cause of cancer-related death in the pediatric age group, and this is due to the development of pulmonary metastases that fail...
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Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential...
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Current development of mTOR inhibitors as anticancer agents
Mammalian target of rapamycin (mTOR) is a kinase that functions as a master switch between catabolic and anabolic metabolism and as such is a target...
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Lipid-based delivery of combinations of antisense oligodeoxynucleotides for the in vitro inhibition of HIV-1 replication
We evaluated a new approach to AIDS therapy by using combinations of oligodeoxynucleotides (ODNs), delivered with a lipid-based carrier system, that...
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NPY Y5 Receptor Subtype
Neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are endogenous 36-amino acid peptides belonging to the same family. Different...
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Gene Therapy Strategies for Inhibition of HIV
Most of the HIV proteins and virtually every stage in the HIV life cycle can be viewed as a potential site for inhibition. Several of the HIV...