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A novel de novo KCNB1 variant altering channel characteristics in a patient with periventricular heterotopia, abnormal corpus callosum, and mild seizure outcome
KCNB1 encodes the α-subunit of Kv2.1, the main contributor to neuronal delayed rectifier potassium currents. The subunit consists of six...
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Current Evidence and Future Perspectives About Herbal Therapeutics for Cancer Therapy
Cancer leads to dynamic alterations in the genome and causes millions of deaths worldwide. It has become a major health concern in the past decades...
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Gold nanoparticles and gold nanorods in the landscape of cancer therapy
Cancer is a grievous disease whose treatment requires a more efficient, non-invasive therapy, associated with minimal side effects. Gold...
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Nanocomposite hydrogel microneedles: a theranostic toolbox for personalized medicine
Due to the severity and high prevalence of cancer, as well as its complex pathological condition, new strategies for cancer treatment and diagnostics...
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Advanced Drug Delivery Strategies for Metal-Based Anticancer Drugs
Metal-based anticancer drugs, such as platinum complexes (e.g., cisplatin, carboplatin, and oxaliplatin), have demonstrated remarkable efficacy in...
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Ethical Aspects of Cancer Nanomedicine: What We Do Not Know
In this chapter, we have discussed the often-overlooked ethical principles related to cancer nanomedicine and its development. Cancer nanomedicine is...
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Transmissible Animal Tumors as Models for Cancer Research
Transmissible and transplantable animal models of tumors were applied by many investigators to scrutinize the mechanisms involved during the progress...
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A comprehensive review on different approaches for tumor targeting using nanocarriers and recent developments with special focus on multifunctional approaches
BackgroundDespite tremendous advancements in cancer treatment delivery, we are still far from achieving successful cancer prognosis and cure. The use...
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Animal Model-Based Studies to Evaluate the Lipid-Based Drug Delivery Nanocarriers for Cancer Treatment
In an effort to find products and processes for human healthcare, experimental objects and materials that can simulate the human body have been used...
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The Toxicology Investigators Consortium 2022 Annual Report
Since 2010, medical toxicology physicians from the American College of Medical Toxicology (ACMT) Toxicology Investigators Consortium (ToxIC) have...
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A review of major causative genes in congenital myopathies
In this review, we focus on congenital myopathies, which are a genetically heterogeneous group of hereditary muscle diseases with slow or minimal...
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New opportunities for RGD-engineered metal nanoparticles in cancer
The advent of nanotechnology has opened new possibilities for bioimaging. Metal nanoparticles (such as gold, silver, iron, copper, etc.) hold...
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Microminiaturization of Multichannel Multifrequency Radiographs
Due to the COVID-19 epidemic, the challenge of introducing methods for investigating patients reducing or eliminating the probability of infection of...
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A population study of clinically actionable genetic variation affecting drug response from the Middle East
Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to...
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Applications of Nanotechnology in Converging the Biomarker Science for Advancement in Cancer Detection and Treatment
Cancer biomarkers with high selectivity, specificity, and reproducibility assume fundamental task in diagnosis, prognosis, and prediction of therapy...
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Mitochondrial ROS driven by NOX4 upregulation promotes hepatocellular carcinoma cell survival after incomplete radiofrequency ablation by inducing of mitophagy via Nrf2/PINK1
BackgroundThe recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains a major clinical problem. Cells that survive...
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Translating Animal Models of Ischemic Stroke to the Human Condition
Ischemic stroke is a leading cause of death and disability. However, very few neuroprotective agents have shown promise for treatment of ischemic...
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A Brief Explanation on Surgical Approaches for Treatment of Different Brain Tumors
The main goal of brain tumorBrain tumor surgerySurgery is to achieve gross total tumor resection without postoperative complicationsComplication and...
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Enhancing nasopharyngeal carcinoma cell radiosensitivity by suppressing AKT/mTOR via CENP-N knockdown
ObjectiveInvestigating the impact of centromere protein N (CENP-N) on radiosensitivity of nasopharyngeal carcinoma (NPC) cells.
Methods ...
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Pilot Experiment on Non-Invasive Non-Thermal Disintegration of Human Mucinous Breast Carcinoma Ex Vivo Using Boiling Histotripsy
We present the results of a pilot study demonstrating the feasibility of non-invasive non-thermal disintegration of human mucinous carcinoma of the...