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NOD-like receptor-mediated plant immunity: from structure to cell death
Animal and plant immune systems use intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) to detect pathogens,...
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Cellular Therapies for Cancer: Chimeric Antigen Receptor T Cells (CAR-T)
Chimeric antigen receptor T cell (CAR-T), a novel modality of adoptive cellular therapy, is characterized by the expression of chimeric antigen...
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Association of progesterone receptor status with 21-gene recurrence score and survival among patients with estrogen receptor-positive breast cancer
BackgroundProgesterone receptor (PR)-negative tumors have been shown to have worse prognosis and were underrepresented in recent trials on patients...
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Immunogenic cell stress and death
Dying mammalian cells emit numerous signals that interact with the host to dictate the immunological correlates of cellular stress and death. In the...
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Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils
Inhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However,...
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Luteolin Protects Against 6-Hydoroxydopamine-Induced Cell Death via an Upregulation of HRD1 and SEL1L
Parkinson’s Disease (PD) is caused by many factors and endoplasmic reticulum (ER) stress is considered as one of the responsible factors for it. ER...
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Role of Non-Receptor-Type Tyrosine Phosphatases in Brain-Related Diseases
The non-receptor protein tyrosine phosphatase is a class of enzymes that catalyze the dephosphorylation of phosphotyrosines in protein molecules....
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Biological roles of A-to-I editing: implications in innate immunity, cell death, and cancer immunotherapy
Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs)....
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P2X7 Receptor: an Emerging Target in Alzheimer’s Disease
Alzheimer’s disease (AD) is a major cause of age-related dementia, which is becoming a global health crisis. However, the pathogenesis and etiology...
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Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury
Ischemic stroke is one of the major causes of morbidity and mortality, affecting millions of people worldwide. Inevitably, the interruption of...
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Androgen Receptor Signaling: A Central and Evolving Theme in Prostate Cancer Treatment
The biological function of the male hormones (androgens) is orchestrated through the activation of the androgen receptor-mediated signaling events...
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SEL1L preserves CD8+ T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis
SEL1L-mediated endoplasmic reticulum-associated degradation (ERAD) plays critical roles in controlling protein homeostasis by degrading misfolded or...
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The V-ATPases in cancer and cell death
Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters that can be divided into F-, V-, and A-ATPases according to their...
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NLRP3 inflammasome activation and cell death
The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate immune receptor protein NLRP3, adapter protein ASC, and...
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Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke
Ischemic stroke caused by intracranial vascular occlusion has become increasingly prevalent with considerable mortality and disability, which gravely...
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Analyzing molecular ty** and clinical application of immunogenic cell death-related genes in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is considered one of the most common cancers, characterized by low early detection and high mortality rates,...
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Oleamide Induces Cell Death in Glioblastoma RG2 Cells by a Cannabinoid Receptor–Independent Mechanism
The endocannabinoid system has been associated with antiproliferative effects in several types of tumors through cannabinoid receptor–mediated cell...
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Soluble TREM2 is associated with death and cardiovascular events after acute ischemic stroke: an observational study from CATIS
BackgroundSoluble triggering receptor expressed on myeloid cells 2 (sTREM2), which reflects microglia activation, has been reported closely...
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The landscape of programmed cell death-related lncRNAs in Alzheimer’s disease and Parkinson’s disease
This study delivers a thorough analysis of long non-coding RNAs (lncRNAs) in regulating programmed cell death (PCD), vital for neurodegenerative...
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Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
BackgroundPresence of autoantibodies against α-synuclein (α-syn AAb) in serum of the general population has been widely reported. That such...
