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Combinatorial antitumor effects of amino acids and epigenetic modulations in hepatocellular carcinoma cell lines
Hepatocellular carcinoma (HCC) is a highly fatal form of liver cancer. Recently, the interest in using amino acids as therapeutic agents has...
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Gut microbiota-related metabolite alpha-linolenic acid mitigates intestinal inflammation induced by oral infection with Toxoplasma gondii
BackgroundOral infection with cysts is the main transmission route of Toxoplasma gondii ( T. gondii ), which leads to lethal intestinal inflammation....
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Expression of fatty acid synthase genes and their role in development and arboviral infection of Aedes aegypti
BackgroundFatty acids are the building blocks of complex lipids essential for living organisms. In mosquitoes, fatty acids are involved in cell...
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Whole-Blood Metabolomics of a Rat Model of Repetitive Concussion
Mild traumatic brain injury (mTBI) and repetitive mTBI (RmTBI) are silent epidemics, and so far, there is no objective diagnosis. The severity of the...
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Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance
BackgroundCerebrospinal fluid (CSF) is mainly produced by the choroid plexus (CP) located in brain ventricles. Although derived from blood plasma, it...
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New aspects of amino acid metabolism in cancer
An abundant supply of amino acids is important for cancers to sustain their proliferative drive. Alongside their direct role as substrates for...
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Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats
RationaleDiscovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to...
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Prognostic Value of L-Type Amino Acid Transporter 1 (LAT1) in Various Cancers: A Meta-Analysis
Background and ObjectiveThe L-type amino acid transporter 1 (LAT1, SLC7A5) is overexpressed in various types of cancer and has been thought to assist...
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Quantum Dots: Functionalization and Theranostic Applications
In the last decade, nanotechnology has shown incredible growth and established itself as valuable technology to prepare highly specific biomedical...
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Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients
Processed aconite root (PA), the tuberous root of Aconitum carmichaelii prepared by autoclaving, is a crude drug used in Japanese traditional Kampo...
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Effects of hemp supplementation during resistance training in trained young adults
PurposeHemp contains protein with high concentrations of the branched-chain amino acids leucine, isoleucine, and valine and oils that have...
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Compound amino acid combined with high-dose vitamin B6 attenuate traumatic coagulopathy via inhibiting inflammation by HMGB1/TLR4/NF-κB pathway
BackgroundTraumatic coagulopathy (TC) arises primarily from coagulation system failure to maintain adequate hemostasis after serious blood loss or...
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Metabolomics analysis reveals changes related to pseudocyst formation induced by iron depletion in Trichomonas vaginalis
BackgroundIron is an essential element for cellular functions, such as energy metabolism. Trichomonas vaginalis , a human urogenital tract pathogen,...
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A Comprehensive Pilot Study to Elucidate the Distinct Gut Microbial Composition and Its Functional Significance in Cardio-Metabolic Disease
Cardio-metabolic disease is a significant global health challenge with increasing prevalence. Recent research underscores the disruption of gut...
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Exopolysaccharides from Lactic Acid Bacteria
Lactic acid bacteria (LAB) are continuously arousing interest for their capacity to produce extracellular polysaccharides (EPS) without any health...
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The Redox State of Serum Albumin as a Potential Protein Nutrition Biomarker
Albumin comprises the largest part of total serum proteins in humans and is exclusively synthesized in the liver, before being distributed into the...
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Metabolism and Functions of Amino Acids in the Skin
Amino acids are the building blocks of all proteins, including the most abundant fibrous proteins in the skin, as keratins, collagen and elastin....
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Oral Delivery of Nucleic Acid Therapies for Local and Systemic Action
Nucleic acid (NA) therapy has gained importance over the past decade due to its high degree of selectivity and minimal toxic effects over...
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Microbiome-driven breeding strategy potentially improves beef fatty acid profile benefiting human health and reduces methane emissions
BackgroundHealthier ruminant products can be achieved by adequate manipulation of the rumen microbiota to increase the flux of beneficial fatty acids...
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The Redox State of Serum Albumin as a Potential Protein Nutrition Biomarker
Albumin comprises the largest part of total serum proteins in humans and is exclusively synthesized in the liver, before being distributed into the...