Search
Search Results
-
Food Vacuole as a Drug Target
During the intraerythrocytic stage, the parasite multiplies and utilizes 60–80% of the hemoglobin within 24 h. The parasite moves through various...
-
Polymeric Micelles in the Delivery of Therapeutic Phytoconstituents
Since ancient times, medicinal plants and their phytochemical constituents have been utilized to cure a number of diseases. Currently, various herbal...
-
Making data map-worthy—enhancing routine malaria data to support surveillance and map** of Plasmodium falciparum anti-malarial resistance in a pre-elimination sub-Saharan African setting: a molecular and spatiotemporal epidemiology study
BackgroundIndependent emergence and spread of artemisinin-resistant Plasmodium falciparum malaria have recently been confirmed in Africa, with...
-
Efficacy and safety of pyronaridine-artesunate (Pyramax®) for the treatment of uncomplicated Plasmodium vivax malaria in Northwest Ethiopia
BackgroundDeclining efficacy of chloroquine for the treatment Plasmodium vivax malaria has been reported in different endemic settings in Ethiopia....
-
Is there evidence of anti-malarial multidrug resistance in Burkina Faso?
Recently, Gansané and colleagues published an article on inadequate efficacy of two different forms of artemisinin-based combination therapy (ACT) in...
-
Antimalarial Drugs and Drug Resistance
WHO estimated 241 million malaria cases in 2020 in 85 different malaria-endemic countries, more than in 2019. The reduction of cases due to...
-
Comparative effect of artemether-lumefantrine and artesunate-amodiaquine on gametocyte clearance in children with uncomplicated Plasmodium falciparum malaria in Madagascar
BackgroundGametocytes are the sexual stages ensuring continuity of the development cycle of the parasite, as well as its transmission to humans. The...
-
Role of Nanotechnology Against Malaria: Current Perspectives and Strategies
Numerous malaria treatments have been proposed for over a century, but they have consistently failed to eradicate the disease. This is mainly due to...
-
Efficacy and safety of pyronaridine–artesunate versus artemether–lumefantrine in the treatment of acute uncomplicated malaria in children in South-West Nigeria: an open-labelled randomized controlled trial
BackgroundIn Nigeria, declining responsiveness to artemether–lumefantrine (AL), the artemisinin-based combination therapy (ACT) of choice since 2005,...
-
Efficacy of artesunate-amodiaquine and artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria in Madagascar, 2018
BackgroundSince 2005, artemisinin-based combination therapy (ACT) has been recommended to treat uncomplicated falciparum malaria in Madagascar....
-
Antimicrobial Resistance: A Crisis in the Making
Antimicrobial resistance (AMR) is considered the silent pandemic that threatens the global public health systems and one of the biggest threats to...
-
Modulators of ROS/NF-κB Signaling in Cancer Therapy
Oxidative stress regulates NF-κB signaling pathway and induces the transcription of genes related to apoptosis and cell proliferation. Due to its...
-
Modulators of ROS/NF-κB Signaling in Cancer Therapy
Oxidative stress regulates NF-κB signaling pathway and induces the transcription of genes related to apoptosis and cell proliferation. Due to its...
-
High prevalence of persistent residual parasitemia on days 3 and 14 after artemether–lumefantrine or pyronaridine–artesunate treatment of uncomplicated Plasmodium falciparum malaria in Nigeria
BackgroundMicroscopic evaluation of parasite clearance is the gold standard in antimalarial drug efficacy trials. However, the presence of...
-
Repurposing artemisinins as neuroprotective agents: a focus on the PI3k/Akt signalling pathway
Artemisinin and its derivatives, since their discovery by professor Tu Youyou in the early 1970s, have been the bedrock for the management of malaria...
-
Population pharmacokinetics of primaquine and its metabolites in African males
BackgroundPrimaquine (PQ) is the prototype 8-aminoquinoline drug, a class which targets gametocytes and hypnozoites. The World Health Organization...
-
Biological role and expression of translationally controlled tumor protein (TCTP) in tumorigenesis and development and its potential for targeted tumor therapy
Translationally controlled tumor protein (TCTP), also known as histamine-releasing factor (HRF) or fortilin, is a highly conserved protein found in...
-
Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine and prevalence of molecular markers of anti-malarial drug resistance in children in Togo in 2021
BackgroundArtemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) are the currently recommended first- and second-line therapies for...
-
Optimal balance of benefit versus risk for tafenoquine in the treatment of Plasmodium vivax malaria
A single 300 mg dose of tafenoquine (an 8-aminoquinoline), in combination with a standard 3-day course of chloroquine, is approved in several...
-
Enhancing the antimalarial activity of artesunate
The global challenge to the treatment of malaria is mainly the occurrence of resistance of malaria parasites to conventionally used antimalarials....
