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No significant association between p53 codon 72 Arg/Pro polymorphism and risk of oral cancer
The genetic polymorphism of p53 codon 72 Arg/Pro has been implicated in oral cancer risk, but the results of previous studies remain controversial...
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Mutations in Non-MMR Genes Modifying or Mimicking Lynch Syndrome Phenotype
Lynch syndrome is an inherited cancer predisposition syndrome associated with an increased risk of colorectal, endometrial and many other cancers,...
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Risk factors for gastric cancer in Latin America: a meta-analysis
BackgroundLatin America has among the highest gastric cancer incidence rates in the world, for reasons that are still unknown. In order to identify...
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Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease
Some individuals with a particular disease-causing mutation or genotype fail to express most if not all features of the disease in question, a...
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Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma
Genetic variations in MDM2 , PTEN and P53 might be involved in cancer susceptibility. To assess the contribution of polymorphisms in these three genes...
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Prevalence of TP53 germ line mutations in young Pakistani breast cancer patients
Women from Pakistan and India are more often diagnosed with early-onset breast cancer than Caucasian women. Given that only 12% of Pakistani women...
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A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide association study of 16 million SNPs identified through...
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p53 Arg72Pro and MDM2 309 SNPs in hereditary retinoblastoma
The tumor suppressor p53 and its negative regulator MDM2 have crucial roles in a variety of cellular functions such as the control of the cell cycle,...
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The Basic Elements of a Correct Diagnosis: From Cytohistopathology to Screening
Although most women infected with the Human Papillomavirus (HPV) become negative within 2 years, women with persistent high-risk (HR) infections are...
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Allelic variants of polymorphic genes associated with a higher frequency of chromosome aberrations
Genotypic associations were studied for the frequency of chromosome aberrations in human peripheral blood lymphocytes. Cytogenetic analysis (1000...
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TP 53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients
BackgroundSingle-nucleotide polymorphisms within TP 53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and MDM2 promoter...
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MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor Breslow thickness
A functional single nucleotide polymorphism (SNP) 309 T/G within mouse double minute 2 ( MDM2 ) gene has been linked to onset and outcome of disease in...
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Survey of familial glioma and role of germline p16 INK4A /p14 ARF and p53 mutation
There is increasing recognition of familial propensity to glioma as a distinct clinical entity beyond a few rare syndromes; however its genetic basis...
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A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer
Neoadjuvant radiochemotherapy followed by total mesorectal excision is now the standard treatment for locally advanced rectal cancer. However, tumor...
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The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
Background:The TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis,...
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Have the roles of two functional polymorphisms in breast cancer, R72P in P53 and MDM2-309 in MDM2, become clearer?
Genetic differences between individuals have been predicted to account for disparate outcomes in patients diagnosed with cancer. The search for...
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Genetic polymorphisms of MDM2 and TP53 genes are associated with risk of nasopharyngeal carcinoma in a Chinese population
BackgroundThe tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis. Previous case-control studies also revealed
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Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms
In vitro studies have shown that p53 mediates a protective response against DNA damage by causing either cell-cycle arrest and DNA repair, or...
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Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast
IntroductionNormal gene expression variation is thought to play a central role in inter-individual variation and susceptibility to disease....
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Identification of colorectal cancer patients with tumors carrying the TP53mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy
BackgroundAlthough postoperative chemotherapy is widely accepted as the standard modality for Dukes' stage C or earlier stage colorectal cancer (CRC)...
