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Selection-driven adaptation to the extreme Antarctic environment in the Emperor penguin
The eco-evolutionary history of penguins is characterised by shifting from temperate to cold environments. Breeding in Antarctica, the Emperor...
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SUMO proteins in the cardiovascular system: friend or foe?
Post-translational modifications (PTMs) are crucial for the adaptation of various signalling pathways to ensure cellular homeostasis and proper...
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MicroRNA related prognosis biomarkers from high throughput sequencing data of kidney renal clear cell carcinoma
BackgroundKidney renal clear cell carcinoma (KIRC) is the most common type of kidney cell carcinoma which has the worst overall survival rate. Almost...
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Contribution of TRPC3-mediated Ca2+ entry to taste transduction
The current concept of taste transduction implicates the TASR/PLCβ2/IP 3 R3/TRPM5 axis in mediating chemo-electrical coupling in taste cells of the...
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The kainate receptor GluK2 mediates cold sensing in mice
Thermosensors expressed in peripheral somatosensory neurons sense a wide range of environmental temperatures. While thermosensors detecting cool,...
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Tramadol and Codeine Stacking/Boosting Dose Exposure Induced Neurotoxic Behaviors, Oxidative Stress, Mitochondrial Dysfunction, and Neurotoxic Genes in Adolescent Mice
In spite of the increasing epidemic of pharmaceutical opioids (codeine and tramadol) misuse and abuse among the adolescents, little is known about...
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Artificial Sweeteners in Animal Models of Binge Eating
Rising rates of obesity in most industrialized countries are a major cause of serious medical conditions, including diabetes, heart disease, and...
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Angiogenesis after ischemic stroke
Owing to its high disability and mortality rates, stroke has been the second leading cause of death worldwide. Since the pathological mechanisms of...
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Differential long non-coding RNA expression profile and function analysis in primary Sjogren’s syndrome
BackgroundPrimary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by abnormal immune cell activation. This study aimed to...
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The neural basis of sugar preference
When it comes to food, one tempting substance is sugar. Although sweetness is detected by the tongue, the desire to consume sugar arises from the...
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Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients
AbstractFor over a year, the coronavirus disease 2019 has been affecting the world population by causing severe tissue injuries and death in infected...
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Molecular mechanisms of brain water transport
Our brains consist of 80% water, which is continuously shifted between different compartments and cell types during physiological and...
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Epithelial-mesenchymal transition process during embryo implantation
The epithelial to mesenchymal transition (EMT) in endometrial epithelial and trophectoderm cells is essential for the progression of embryo...
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Protein Degradome of Spinal Cord Injury: Biomarkers and Potential Therapeutic Targets
Degradomics is a proteomics sub-discipline whose goal is to identify and characterize protease-substrate repertoires. With the aim of deciphering and...
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The Medical Management of Cerebral Edema: Past, Present, and Future Therapies
Cerebral edema is commonly associated with cerebral pathology, and the clinical manifestation is largely related to the underlying lesioned tissue....
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Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer
Despite numerous observations regarding the relationship between DNA methylation changes and cancer progression, only a few genes have been verified...
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Predictive genomic tools in disease stratification and targeted prevention: a recent update in personalized therapy advancements
In the current era of medical revolution, genomic testing has guided the healthcare fraternity to develop predictive, preventive, and personalized...
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Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis
BackgroundIn multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), inflammation is perpetuated by both infiltrating leukocytes...
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Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases
Cells in the brain are surrounded by extracellular space (ECS), which forms porous nets and interconnected routes for molecule transportation. Our...
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Effects of calcium-binding sites in the S2–S3 loop on human and Nematostella vectensis TRPM2 channel gating processes
As a crucial signaling molecule, calcium plays a critical role in many physiological and pathological processes by regulating ion channel activity....