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Targeting tumour-reprogrammed myeloid cells: the new battleground in cancer immunotherapy
Tumour microenvironment is a complex ecosystem in which myeloid cells are the most abundant immune elements. This cell compartment is composed by...
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Clinical application of targeted tumour sequencing tests for detecting ERBB2 amplification and optimizing anti-HER2 therapy in gastric cancer
BackgroundEvaluation of human epidermal growth factor receptor 2 (HER2) overexpression caused by erb-b2 receptor tyrosine kinase 2 ( ERBB2 )...
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Immune Cell Trafficking in the Lymphatics, Hyaluronan Biology and Tumour Metastasis
As an integral part of the immune system, the lymphatics enable immune surveillance by shepherding the migration of antigen-laden immune cells to...
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Biology, vulnerabilities and clinical applications of circulating tumour cells
In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from...
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Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids
Predicting the toxicity of cancer immunotherapies preclinically is challenging because models of tumours and healthy organs do not typically fully...
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Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy...
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Risk factors for cancer of unknown primary: a literature review
Cancer of Unknown Primary (CUP) is metastatic cancer with an unidentifiable primary tumour origin during life. It remains difficult to study the...
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C-type lectin receptor Dectin-1 blockade on tumour-associated macrophages improves anti-PD-1 efficacy in gastric cancer
BackgroundThis study aimed to investigate the expression and clinical significance of Dendritic cell-associated C-type lectin-1 (Dectin-1) in gastric...
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Prevalence of tumour-infiltrating CD103+ cells identifies therapeutic-sensitive prostate cancer with poor clinical outcome
BackgroundThe clinical significance and immune correlation of CD103 + cells in prostate cancer (PCa) remain explored.
MethodsIn total, 1080 patients...
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Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer
BackgroundCervical cancer remains one of the most prevalent cancers worldwide. Accumulating evidence suggests that specificity protein 1 (Sp1) plays...
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Tumour-derived extracellular vesicle based vaccines for melanoma treatment
The interest of extracellular vesicles (EVs) in cancer immunotherapy is increasing every day. EVs are lipid bilayer vesicles released by most cells,...
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Clinical practice guidelines for the diagnosis and surveillance of BAP1 tumour predisposition syndrome
BRCA1-associated protein-1 (BAP1) is a recognised tumour suppressor gene. Germline BAP1 pathogenic/likely pathogenic variants are associated with...
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Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution
Cancer development is an evolutionary process. A key selection pressure is exerted by therapy, one of the few players in cancer evolution that can be...
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A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor
Vectors that facilitate the engineering of T cells that can better harness endogenous immunity and overcome suppressive barriers in the tumour...
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Obese mammary tumour-bearing mice are highly sensitive to doxorubicin-induced hepatotoxicity
BackgroundBreast cancer is a major health burden for women, worldwide. Lifestyle-related risk factors, such as obesity and being overweight, have...
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Role of Tumour-Associated Macrophages in Colon Cancer Progression and Its Therapeutic Targeting
Cancer tissues are invariably infiltrated by cells of the immune system, and macrophages constitute the major portion of these. Experimental pieces...
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Immune cell infiltration and inflammatory landscape in primary brain tumours
BackgroundPrimary malignant brain tumours are more than one-third of all brain tumours and despite the molecular investigation to identify cancer...
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Activatable near-infrared probes for the detection of specific populations of tumour-infiltrating leukocytes in vivo and in urine
Tracking the immune microenvironment of tumours is essential for understanding the mechanisms behind the effectiveness of cancer immunotherapies....
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Tumour-associated myeloid cells expressing IL-10R2/IL-22R1 as a potential biomarker for diagnosis and recurrence of pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor survival rate, largely due to the lack of early diagnosis....
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Persistence of peripheral CD8 + CD28− T cells indicates a favourable outcome and tumour immunity in first-line HER2-positive metastatic breast cancer
BackgroundThe contradictory role of CD8 + CD28− T cells in tumour immunity has been reported, while their biological and clinical significance in...
