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Gestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure
BackgroundPhysiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA...
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Risk Factors for Postpartum Depression Based on Genetic and Epigenetic Interactions
Postpartum depression (PPD) is a serious mood disorder that tends to occur after the delivery, which may bring lifelong consequences to women and...
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Parental Behavior
Maternal behavior (MB) in mammals is a goal-directed behavior adapted for ensuring the survival of a female’s offspring. It includes a constellation...
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Preeclampsia as a possible risk factor for memory impairment, anxiety- and depressive-like behavior in offspring
RationalePreeclampsia is a condition that can affect the health in offspring at adult life. The effect on several systems has been described, but...
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Optimizing the role of ‘lead mothers’ in seasonal malaria chemoprevention (SMC) campaigns: formative research in Kano State, northern Nigeria
BackgroundSeasonal malaria chemoprevention (SMC) is a safe and effective intervention for preventing malaria in children under 5 years of age. Lead...
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Epigenetics of prenatal stress in humans: the current research landscape
Fetal exposure to prenatal stress can have significant consequences on short- and long-term health. Epigenetic mechanisms, especially DNA methylation...
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Cognition and Neuroplasticity During Pregnancy and Postpartum
Many physiological changes occur during pregnancy and in the postpartum, including dramatic fluctuations in circulating hormones. These changes...
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Recent Neuroscience Advances in Human Parenting
The transition to parenthood entails brain adaptations to the demands of caring for a newborn. This chapter reviews recent neuroscience findings on...
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Grief and Bereavement Support in Palliative Care
Grief begins upon the diagnosis of a life-limiting illness and continues as an ever-present companion throughout the illness and after the death of a...
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HPV infection and its correlation with p53 and Bcl-2 among pregnant mothers and their infants
The investigation of perinatal transmission of HPV is vital for early screening of cervical/oral cancers. Here, transmission of HPV from the pregnant...
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The Human Gut Microbiome in Health, Disease, and Therapeutics
Various past studies have demonstrated that healthy gut microbiota is inevitable for maintenance of gut homeostasis as well as lowering the chances...
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Neonatal outcomes after gamma-aminobutyric acid analog use during pregnancy: a meta-analysis of cohort studies
BackgroundGamma-aminobutyric acid (GABA) analogs are being used by an increasing number of reproductive-age women. However, there is concern...
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Vertical transmission of the gut microbiota influences glucose metabolism in offspring of mice with hyperglycaemia in pregnancy
BackgroundHyperglycaemia in pregnancy (HIP) is a common metabolic disorder that not only poses risks to maternal health but also associates with an...
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Enterovirus B types cause severe infection in infants aged 0–3 months
BackgroundEnterovirus (EV) infections are being increasingly seen in younger infants, often being more severe than in older children. The risk...
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Globally elevated levels of histone H3 lysine 9 trimethylation in early infancy are associated with poor growth trajectory in Bangladeshi children
BackgroundStunting is a global health problem affecting hundreds of millions of children worldwide and contributing to 45% of deaths in children...
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Genetics and Epigenetics of Manganese Toxicity
Purpose of ReviewAt elevated levels, the essential element manganese (Mn) is neurotoxic and increasing evidence indicates that environmental Mn...
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A Case Report of IPEX Syndrome with Neonatal Diabetes Mellitus and Congenital Hypothyroidism as the Initial Presentation, and a Systematic Review of neonatal IPEX
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is a serious disorder, which may comprise diabetes, thyroid disease,...
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A global multicohort study to map subcortical brain development and cognition in infancy and early childhood
The human brain grows quickly during infancy and early childhood, but factors influencing brain maturation in this period remain poorly understood....
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Novel likely pathogenic variant in the EYA1 gene causing Branchio oto renal syndrome and the exploration of pathogenic mechanisms
ObjectiveBranchio-oto-renal syndrome (BOR, OMIM#113,650) is a rare autosomal dominant disorder that presents with a variety of symptoms, including...
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Screening of Spinal Muscular Atrophy Carriers and Prenatal Diagnosis in Pregnant Women in Yancheng, China
Spinal muscular atrophy (SMA) is a neuromuscular disorder with an autosomal recessive inheritance pattern. Patients with severe symptoms may suffer...
