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Gambogic Acid Disrupts Toll-like Receptor4 Activation by Blocking Lipopolysaccharides Binding to Myeloid Differentiation Factor 2
Our body’s immune system has defense mechanisms against pathogens such as viruses and bacteria. Immune responses are primarily initiated by the...
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Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing
In the past 15 years, the proteasome has been validated as an anti-cancer drug target and 20S proteasome inhibitors (such as bortezomib and...
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Cytotoxicity of anti-tumor herbal Marsdeniae tenacissimae extract on erythrocytes
Marsdeniae tenacissimae extract (MTE) has been used as an adjuvant medicine for cancer therapy for a long time. Although massive studies demonstrated...
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Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones
PurposePreviously, compounds containing a piperidone structure have been shown to be highly cytotoxic to cancer cells. Recently, we found that the...
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Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein
Multidrug resistance (MDR) is the major impediment to cancer chemotherapy. The expression of lung resistance-related protein (LRP), a non-ATP-binding...
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Emerging small molecule approaches to enhance the antimyeloma benefit of proteasome inhibitors
Multiple myeloma (MM) is a clonal plasma cell malignancy which, despite recent treatment advances, remains incurable in the vast majority of the over...
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Mangostanaxanthones III and IV: advanced glycation end-product inhibitors from the pericarp of Garcinia mangostana
Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a...
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Anti-apoptotic Bcl-2
The B-cell lymphoma/leukemia 2 (BCL-2) family represents a group of proteins involved in the regulation of the intrinsic (mitochondrial) apoptotic...
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Functional Relevance of Deubiquitinases in Life and Disease
Deubiquitinases (DUBs) are critical regulators of ubiquitin-mediated signaling pathways through their ability to cleave the isopeptide bond that...
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Challenges in Multiple Myeloma Chemoprevention: Potential Role of Natural, Synthetic and Endogenous Molecules
Carcinogenesis is a process generally occurring in tumors characterized by a long latency, in which the accumulation of molecular aberrations leads...
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Microplate-Based Whole Zebrafish Caspase 3/7 Assay for Screening Small Molecule Compounds
In this research, using a commercially available human specific caspase 3/7 chemiluminescent test kit (Caspase 3/7 Glo, Promega, Madison, WI),...
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The Development and Achievement of Polymeric Nanoparticles for Cancer Drug Treatment
Limited aqueous solubility, stability, and bioavailability are common characteristics of hydrophobic drugs which impedes the delivery of drugs to...
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An external sensing system in Plasmodium falciparum-infected erythrocytes
BackgroundA number of experiments have previously indicated that Plasmodium falciparum -infected erythrocytes (pRBC) were able to sense host...
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A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling
The natural compound camptothecin (CPT) derivatives have widely been used for anti-cancer treatments, including lung cancer. However, many...
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Recent Research on Bioactive Xanthones from Natural Medicine: Garcinia hanburyi
Garcinia hanburyi , a tropical plant found in south Asia, has a special long history in the development of both medicine and art. This review mainly...
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Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells
GW501516 is a selective and high-affinity synthetic agonist of peroxisome proliferator-activated receptor β/δ (PPARβ/δ). This molecule promoted the...
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Construction and application of a lung cancer stem cell model: antitumor drug screening and molecular mechanism of the inhibitory effects of sanguinarine
Lung cancer is a neoplasm with a 5-year survival rate of less than 15 % and a leading cause of death worldwide, despite recent progress in treatment...
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Garcinol and Its Role in Chronic Diseases
The various bioactive compounds isolated from leaves and fruits of Garcinia sps plants, have been characterized and experimentally demonstrated to...
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Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling
Background:Gambogic acid (GA) has been reported to have potent anticancer activity and is authorised to be tested in phase II clinical trials for...
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New prospects for targeting telomerase beyond the telomere
Telomerase activity is responsible for the maintenance of chromosome end structures (telomeres) and cancer cell immortality in most human...
