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Clinical Neuroinnovation: Ethical Frameworks and Emerging Issues
This chapter summarizes complementary prescriptive, principles-based, and empirical (descriptive) ethics approaches in research and treatment of...
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The Experience of Using Multipotent Mesenchymal Stromal Cells in the Treatment of Severe Recurrent Cholangitis in Children with Biliary Atresia after Kasai Surgery
This article describes the experience of application of multipotent mesenchymal stromal cells in the complex therapy of severe recurrent cholangitis...
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Acute lung injury: a view from the perspective of necroptosis
BackgroundALI/ARDS is a syndrome of acute onset characterized by progressive hypoxemia and noncardiogenic pulmonary edema as the primary clinical...
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Recent Developments in Additive-Manufactured Intermetallic Compounds for Bio-Implant Applications
PurposeThis paper reviews the recent developments of two newly developed intermetallic compounds (IMCs) of metallic glasses (MGs) and high-entropy...
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Cancer and Apoptosis
Cancer is an uncontrolled growth of normal cells due to unchecked regulatory mechanisms working inside the rapidly dividing cells. In this complex...
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Recurrent Neural Networks (RNNs): Architectures, Training Tricks, and Introduction to Influential Research
Recurrent neural networks (RNNs) are neural network architectures with hidden state and which use feedback loops to process a sequence of data that...
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Heterogeneity in Tuberculosis
Tuberculosis (TB), an age-old disease, has troubled the humanHuman race despite advances in diagnosis and treatment. Mycobacterium...
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Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease
The complex multifactorial nature of AD pathogenesis has been highlighted by evidence implicating additional neurodegenerative mechanisms, beyond...
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Stereolithography (SLA) in Pharmaceuticals
Commercial stereolithography (SLA) 3D printing has been around for over three decades. However, only recently the technology has been employed in...
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Zelltod und replikative Seneszenz bei Krebs
Für kontinuierliches Wachstum müssen Krebszellen die Barrieren überwinden, die durch terminale Differenzierung, replikative Seneszenz und Zelltod...
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The Neuroprotection Effects of Exosome in Central Nervous System Injuries: a New Target for Therapeutic Intervention
Central nervous system (CNS) injuries, including traumatic brain injury (TBI), spinal cord injury (SCI), and subarachnoid hemorrhage (SAH), are the...
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Role of ROS in Triggering Death Receptor-Mediated Apoptosis
Reactive oxygen species (ROS) are continuously produced and removed in live systems. In different concentrations, ROS has beneficial or harmful...
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Oncology: Biochemists’ Perspective
In this chapter, the stepwise development of carcinogenesis has been addressed along with biochemical aspects of cancer cells. Different physical,...
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Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways
The development of acute liver injury can result in liver cirrhosis, liver failure, and even liver cancer, yet there is currently no effective...
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PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment
This comprehensive review explores the intricate mechanisms of PANoptosis and its implications in cancer. PANoptosis, a convergence of apoptosis,...
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Replication and extension of a model predicting response to psilocybin
BackgroundRecent research demonstrated the potential of psychedelic drugs as treatment for depression and death-related anxiety and as an enhancement...
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Apoptosis and its pathways as targets for intracellular pathogens to persist in cells
Apoptosis is a finely programmed process of cell death in which cells silently dismantle and actively participate in several operations such as...
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Investigation of reactive astrogliosis effect on post-stroke cognitive impairment
BackgroundThe aim of this study is to investigate the associations between post-stroke cognitive impairment (PSCI) severity and reactive astrogliosis...
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Pharmacodynamic Evaluation: Ocular Pharmacology
The eye is a specialized organ that provides a relatively easy access for direct visualization of the different anatomical structures and assessment...
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The Frontotemporal Dementia Prevention Initiative: Linking Together Genetic Frontotemporal Dementia Cohort Studies
Around one-third of frontotemporal dementia (FTD) is autosomal dominant with the major genetic causes being mutations in MAPT, GRN and C9orf72....