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Epithelial–Mesenchymal Transition and Cancer Stem Cells
Epithelial–mesenchymal transition (EMT), a cellular phenotypic change from epithelial to mesenchymal-like features, is related to the resistance and...
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Novel sequential treatment with palbociclib enhances the effect of cisplatin in RB-proficient triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) is a highly aggressive malignancy that lacks sensitivity to chemotherapy, endocrine therapy or...
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Hedyotis diffusae Herba-Andrographis Herba inhibits the cellular proliferation of nasopharyngeal carcinoma and triggers DNA damage through activation of p53 and p21
Dysregulation of the cell cycle and the resulting aberrant cellular proliferation has been highlighted as a hallmark of cancer. Certain traditional...
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Proteolysis-targeting chimeras (PROTACs) in cancer therapy
Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two...
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The Intricacy of ROS in Cancer Therapy Resistance
Cancer is one of the notable causes of death universally due to the emergence of therapy resistance despite the evolution of encouraging therapeutic...
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Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer
Breast cancer is the second leading cause of death for women worldwide. The heterogeneity of this disease presents a big challenge in its therapeutic...
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Human papillomavirus-mediated carcinogenesis and tumor progression
High-risk human papillomaviruses (HPV) cause 5% of all human cancers and are primary etiologic agents of cervical, anal, and oropharyngeal cancer....
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Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance
Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer treatment modalities that are widely used due to their...
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Protein post-translational modifications in the regulation of cancer hallmarks
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety...
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The G Protein Estrogen Receptor (GPER) is involved in the resistance to the CDK4/6 inhibitor palbociclib in breast cancer
BackgroundThe cyclin D1-cyclin dependent kinases (CDK)4/6 inhibitor palbociclib in combination with endocrine therapy shows remarkable efficacy in...
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PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis
BackgroundAltered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1...
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Transcriptional Control Leading to Clinical Outcomes in Breast Cancer Cases
Transcription is an important event that use information from a gene and make its protein. Specific transcription factors are involved in the process...
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Transcription factor p53-mediated activation of miR-519d-3p and downregulation of E2F1 attenuates prostate cancer growth and metastasis
Prostate cancer (PCa) is a commonly diagnosed malignancy in men. The transcription factor p53, a well-known cancer suppressor, has been extensively...
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Cyclin-dependent kinase inhibitors in head and neck cancer and glioblastoma—backbone or add-on in immune-oncology?
Cyclin-dependent kinases (CDK) control the cell cycle and play a crucial role in oncogenesis. Pharmacologic inhibition of CDK has contributed to the...
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Dynamical Methods to Study Interaction in Proteins Facilitating Molecular Understanding of Cancer
Protein-protein interactions coordinate functions within a cell making it fit to survive. Some of the proteins in this network of interactions act as...
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Targeting transcription cycles in cancer
Accurate control of gene expression is essential for normal development and dysregulation of transcription underpins cancer onset and progression....
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Role of microRNA-34b-5p in cancer and injury: how does it work?
MicroRNAs (miRNAs or miRs) are a class of noncoding single-stranded RNAs that can regulate gene expression by binding to the untranslated sequences...
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The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex
BackgroundAs a novel type of non-coding RNA, circular RNAs (circRNAs) play a critical role in the initiation and development of various diseases,...
