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No evidence of amplified Plasmodium falciparum plasmepsin II gene copy number in an area with artemisinin-resistant malaria along the China–Myanmar border
BackgroundThe emergence and spread of artemisinin resistance in Plasmodium falciparum poses a threat to malaria eradication, including China’s plan...
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Knowledge and practices of private pharmacy auxiliaries on malaria in Abidjan, Côte d’Ivoire
BackgroundThe emergence of resistance to artemisinin derivatives in Southeast Asia constitutes a serious threat for other malaria endemic areas,...
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Artemether-lumefantrine efficacy among adults on antiretroviral therapy in Malawi
BackgroundWhen people with human immunodeficiency virus (HIV) infection (PWH) develop malaria, they are at risk of poor anti-malarial treatment...
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Current Treatments for Malaria
Antimalarial drug therapy is the recommended measure for malaria patients. In the chapter, the treatment for uncomplicated malaria, severe and...
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Time series analysis of malaria cases to assess the impact of various interventions over the last three decades and forecasting malaria in India towards the 2030 elimination goals
BackgroundDespite the progress made in this decade towards malaria elimination, it remains a significant public health concern in India and many...
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Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy
Cancer cells largely rely on aerobic glycolysis or the Warburg effect to generate essential biomolecules and energy for their rapid growth. The key...
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Natural products and the balancing act of autophagy-dependent/independent ferroptosis in cancer therapy
The control of biological cell death is essential for the body’s appropriate growth. The resistance of cells to the apoptotic process presents a new...
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Modulators of ROS/NF-κB Signaling in Cancer Therapy
Oxidative stress regulates NF-κB signaling pathway and induces the transcription of genes related to apoptosis and cell proliferation. Due to its...
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Malaria epidemiology and anti-malarial drug efficacy in Guinea: a review of clinical and molecular studies
Malaria is one of the leading causes of mortality and morbidity in Guinea. The entire country is considered at risk of the disease. Transmission...
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A qualitative study on determinants of the use of malaria rapid diagnostic test and anti-malarial drug prescription practices by primary healthcare workers in Ebonyi state, Nigeria
BackgroundThe increased availability and use of malaria rapid diagnostic test (RDT) by primary healthcare (PHC) workers has made universal diagnostic...
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Compatibilized Biopolymer-based Core–shell Nanoparticles: A New Frontier in Malaria Combo-therapy
PurposeNano-sized biopolymer-based strategies such as spatio-temporal co-delivery of bioactives could be employed to overcome low bioavailability of...
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Therapeutic efficacy and safety of artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria treatment in Metehara, Central-east Ethiopia
BackgroundMalaria remains a major global health problem although there was a remarkable achievement between 2000 and 2015. Malaria drug resistance,...
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The impact of the private sector co-payment mechanism (PSCM) on the private market for ACT in Nigeria: results of the 2018 cross-sectional outlet and household market surveys
BackgroundThe private sector plays a large role in malaria treatment provision in Nigeria. To improve access to, and affordability of,...
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Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania
BackgroundArtemisinin-based combination therapy (ACT) is the first-line anti-malarial treatment of uncomplicated malaria in most malaria endemic...
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Efficacy of three anti-malarial regimens for uncomplicated Plasmodium falciparum malaria in Cambodia, 2009–2011: a randomized controlled trial and brief review
BackgroundAnti-malarial resistance remains an important public health challenge in Cambodia. The effectiveness of three therapies for uncomplicated...
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A review on reported phytochemicals as druggable leads with antimalarial potential
The science and practice of drug discovery and development is primarily benefitted from the natural sources. The chemistry of natural products has...
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Natural compounds targeting nuclear receptors for effective cancer therapy
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatially and temporally. Numerous...
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Nationwide spatiotemporal drug resistance genetic profiling from over three decades in Indian Plasmodium falciparum and Plasmodium vivax isolates
BackgroundDrug resistance is a serious impediment to efficient control and elimination of malaria in endemic areas.
MethodsThis study aimed at...
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Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy
Epigenetics studies heritable genomic modifications that occur with the participation of epigenetic modifying enzymes but without alterations of the...
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Plasmodium falciparum clearance time in Malawian children with cerebral malaria: a retrospective cohort study
BackgroundStandard treatment for both uncomplicated and severe malaria is artemisinin derivatives. Delayed parasite clearance times preceded the...
