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The effects of p53 Arg72Pro polymorphism on glioma susceptibility: a meta-analysis
The potentially functional polymorphism Arg72Pro in p53 gene has been implicated in glioma risk, but published studies have mixed findings. The aim...
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Association between p53 codon 72 polymorphism and sarcoma risk among Caucasians
Many published data on the association between p53 codon 72 polymorphism and sarcoma risk showed inconclusive results. The present study was designed...
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TP53 alterations and colorectal cancer predisposition in south Indian population: A case-control study
The objective of the present study was to investigate the association between TP53 gene single nucleotide polymorphisms (SNPs) and colorectal cancer...
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RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population
Common variants of multiple genes play a role in glioma onset. However, research related to astrocytoma, the most common primary brain neoplasm, is...
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Comparative study and meta-analysis of meta-analysis studies for the correlation of genomic markers with early cancer detection
A large number of common disorders, including cancer, have complex genetic traits, with multiple genetic and environmental components contributing to...
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Association of p53 codon 72 polymorphism with prostate cancer: an update meta-analysis
Many studies have been conducted to explore the association between p53 codon 72 polymorphism and prostate cancer (PCa). However, the results remain...
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Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
p53 is involved in stress response, metabolism and cardiovascular functioning. The C-allele of rs1042522 in the gene encoding for p53 is associated...
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Genetic variations in TP53 binding sites are predictors of clinical outcomes in prostate cancer patients
Since the tumor protein p53 (TP53), a transcription factor, plays a crucial role in prostate cancer development and progression, we hypothesized that...
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Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk
The P53 codon 72 polymorphism has been identified as a critical biomarker in modifying the risk of nasopharyngeal cancer (NPC). Many studies have...
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HPV prevalence and genetic predisposition to cervical cancer in Saudi Arabia
BackgroundCervical cancer incidence is low in Saudi Arabian women, suggesting low prevalence to HPV infection due to environmental, cultural and...
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RETRACTED ARTICLE: SNPs in genes implicated in radiation response are associated with radiotoxicity and evoke roles as predictive and prognostic biomarkers
BackgroundBiomarkers are needed to individualize cancer radiation treatment. Therefore, we have investigated the association between various risk...
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Genetic Epidemiology and Pancreatic Cancer
Gene mutations that are associated with cancer syndromes explain a small portion of pancreatic cancer cases. The majority of the sporadic pancreatic...
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P53 codon 72 Arg/Pro polymorphism and glioma risk: an updated meta-analysis
P53 codon 72 Arg/Pro is a C/G variation upstream of the p53 gene on human chromosome 17p13. Many case–control studies have investigated the...
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A systematic review of cancer GWAS and candidate gene meta-analyses reveals limited overlap but similar effect sizes
Candidate gene and genome-wide association studies (GWAS) represent two complementary approaches to uncovering genetic contributions to common...
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P53 codon 72 Arg/Pro polymorphism and lung cancer risk in Asians: an updated meta-analysis
The polymorphism of p53 codon 72, a transversion of G to C (Arg to Pro), has been demonstrated to be associated with the risk for lung cancer....
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The Inheritance of p53
The p53 pathway constitutes a major cellular gene network that is crucial in directing the suppression of cancer formation, mediating the response to...
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P53 codon 72 polymorphism and lung cancer risk: evidence from 27,958 subjects
The role of p53 codon 72 polymorphism in the development of lung cancer remains obscure due to inconsistent findings of individual case–control...
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Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case–control study
BackgroundChronic obstructive pulmonary disease (COPD) is influenced by both environmental and genetic factors. Few gene studies of the Chinese...
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Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk
Previous studies regarding the association of p53 codon 72 Arg/Pro polymorphism with hepatocellular carcinoma (HCC) risk have provided conflicting...
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Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer
Some 15–20% of multiple adenomatous polyposis have no genetic explanation and 20–30% of colorectal cancer (CRC) cases are thought to be due to...