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Knockdown of TFRC suppressed the progression of nasopharyngeal carcinoma by downregulating the PI3K/Akt/mTOR pathway
BackgroundThe transferrin receptor (TfR) encoded by TFRC gene is the main cellular iron importer. TfR is highly expressed in many cancers and is...
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YY1: a key regulator inhibits gastric cancer ferroptosis and mediating apatinib-resistance
ObjectiveGastric cancer (GC) stands as a prevalent and deadly global malignancy. Despite its role as a preoperative neoadjuvant therapy, Apatinib’s...
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Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice
Familial hypercholesterolemia (FH) is a genetic hyperlipidemia characterized by elevated concentrations of plasma LDL cholesterol. Statins are not...
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Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages
BackgroundTumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role...
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Transferrin receptor-involved HIF-1 signaling pathway in cervical cancer
Cervical cancer is one of the most prevalent gynecologic malignancies and has remained an intractable cancer over the past decades. We analyzed...
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Identification and in vivo characterization of a brain-penetrating nanobody
BackgroundPreclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed...
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Characteristics of T cell premature senescence in maintenance hemodialysis patients
BackgroundUremia-associated immunodeficiency, mainly characterized by T cell dysfunction, exists in patients on maintenance hemodialysis (MHD) and...
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Activation of NMDA receptors in brain endothelial cells increases transcellular permeability
Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose. In...
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Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery
Current strategies to identify ligands for brain delivery select candidates based on preferential binding to cell-membrane components (CMC) on brain...
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Lipocalin-2-Mediated Insufficient Oligodendrocyte Progenitor Cell Remyelination for White Matter Injury After Subarachnoid Hemorrhage via SCL22A17 Receptor/Early Growth Response Protein 1 Signaling
Insufficient remyelination due to impaired oligodendrocyte precursor cell (OPC) differentiation and maturation is strongly associated with...
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Protective Effect of Sevoflurane Preconditioning on Cardiomyocytes Against Hypoxia/Reoxygenation Injury by Modulating Iron Homeostasis and Ferroptosis
To investigate the mechanism whereby sevoflurane (Sev) protects cardiomyocytes from hypoxia/reoxygenation (H/R) injury. The rat cardiomyocyte line...
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Preparation of Notch-4 Receptor Containing Quartz Crystal Microbalance Biosensor for MDA MB 231 Cancer Cell Detection
Quartz crystal microbalance (QCM) is a highly sensitive system that is used as a biosensor for biomolecules and cells. Detection and characterization...
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Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells
Cerebral malaria is the most serious complication of malaria infection, with 26% of surviving children having neurological sequelae, which may be...
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ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles
PurposeApolipoprotein E2 (ApoE2) gene therapy is a potential disease-modifying therapy for Alzheimer’s disease (AD). We investigated the potential of...
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The Significance of the Choroid Plexus for Cerebral Iron Homeostasis
The homeostasis of the brain interstitial fluid is sustained by two brain barriers, i.e. the blood-brain barrier (BBB) formed by brain capillary...
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Genetic diversity of Plasmodium vivax reticulocyte binding protein 2b in global parasite populations
BackgroundPlasmodium vivax reticulocyte binding protein 2b (PvRBP2b) plays a critical role in parasite invasion of reticulocytes by binding the...
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Association of Ferroptosis with Severity and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: A Case-control Study
Ferroptosis, an iron-dependent form of cell death, is characterized by intracellular accumulation of iron and reactive oxygen species-induced lipid...
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Dexmedetomidine attenuates ferroptosis by Keap1-Nrf2/HO-1 pathway in LPS-induced acute kidney injury
Previous research has demonstrated that Dexmedetomidine (DEX), an α2 adrenergic agonist commonly used for its sedative and analgesic properties, can...
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Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
BackgroundTransferrin receptor 1 (TfR1) mediated brain delivery of antibodies could become important for increasing the efficacy of emerging...
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Implication of asymptomatic and clinical Plasmodium falciparum infections on biomarkers of iron status among school-aged children in Malawi
BackgroundIron status is considered as a continuum from an iron deficiency with anaemia, without anaemia, varying amounts of stored iron to iron...
