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Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for rapid and sensitive protein detection and quantification in simple and...
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Bright New World: Principles of Fluorescence and Applications in Spectroscopy and Microscopy
The study of fluorescence has revolutionized biomedical research. Since it was first described almost two centuries ago, fluorescence has transformed...
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Principles of Analytical Chemistry for Toxicology
In the first section, a historical summary of analytical chemistry is presented. In ancient history, one function of an analytical chemist was to...
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Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and collaborative drug discovery efforts took place in academia and...
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Principles of Analytical Chemistry for Toxicology
In the first section, a historical summary of analytical chemistry is presented. In ancient history, one function of an analytical chemist was to...
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Advances in targeting ‘undruggable’ transcription factors with small molecules
Transcription factors (TFs) represent key biological players in diseases including cancer, autoimmunity, diabetes and cardiovascular disease....
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Physiologically Based Pharmacokinetic Modelling in Drug Discovery and Clinical Development: A Treatise on Concepts, Model Workflow, Credibility, Application and Regulatory Landscape
Physiologically based pharmacokinetic modelling (PBPK) approach considers the body as a multi-compartment system where physiological organs and...
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Single-Molecule Localization Microscopy Propelled by Small Organic Fluorophores with Blinking Properties
Super-resolution fluorescence imaging by single-molecule localization microscopy (SMLM) has paved the way for a better understanding of cellular...
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Harnessing the necessary nitrogen atom in chemical biology and drug discovery
Despite 80 years of progress in modern small molecule drug discovery, medicinal chemists still struggle to minimize the number and duration of design...
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Sensors Based on Peptides and Proteins as Recognition Units
Peptides and proteins areRecognition units the major actors in biological world participating on different steps of biochemical reactions and their...
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HIV-1 and HBV RNase H as Metal-Chelating Inhibitors: Discovery and Medicinal Chemistry Strategies
Human immunodeficiency viruses (HIV) andHuman Immunodeficiency virus (HIV) hepatitis B viruses (HBV) areHepatitis B virus (HBV) highly pathogenic...
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The Medicinal Chemistry of Zika Virus
Arthropod-borne viruses, also known as arbovirusesArbovirus, are transmitted by bites of infected mosquitoMosquitoes or tick vectorsVectors. In this...
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Identification of osteoporosis ferroptosis-related markers and potential therapeutic compounds based on bioinformatics methods and molecular docking technology
Research background and purposeOsteoporosis (OP) is one of the most common bone diseases worldwide, characterized by low bone mineral density and...
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Localised Delivery of Macromolecules to the Large Intestine: Translation to Clinical Trials
Oral administration of macromolecules aimed at systemic delivery has been at the forefront of pharmaceutical research for over 50 years. Yet, in...
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Roadmap to the Development of mRNA Therapeutics: From Molecule Design and Delivery Strategies to Manufacturing, Quality Control, and Regulatory Considerations
mRNA has been touted as a therapeutic modality since 1990 and has demonstrated potential applications in oncology, protein replacement therapies, and...
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Designing of Smartly Functionalized Theranostic Nanomedicines
The consistent advances in the synthesis of nanoparticles (NPs) enable their potential use in the field of treatment and diagnosis. The NPs that are...
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Neoantigen vaccine nanoformulations based on Chemically synthesized minimal mRNA (CmRNA): small molecules, big impact
Recently, chemically synthesized minimal mRNA (CmRNA) has emerged as a promising alternative to in vitro transcribed mRNA (IVT-mRNA) for cancer...
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Polypharmacology in Drug Design and Discovery—Basis for Rational Design of Multitarget Drugs
Chapter 3 through Chap. 11 introduces the current status of clinical...
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Immune Homeostasis Maintenance Through Advanced Immune Therapeutics to Target Atherosclerosis
Atherosclerosis remains the leading cause of coronary heart disease (CHD) with enormous health and societal tolls. Traditional drug development...
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Copy Number Analysis in a Large Cohort Suggestive of Inborn Errors of Immunity Indicates a Wide Spectrum of Relevant Chromosomal Losses and Gains
Inborn errors of immunity (IEI) are genetically driven disorders. With the advancement of sequencing technologies, a rapidly increasing number of...
