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A new insight into the role of pericytes in ischemic stroke
The functional structure of the blood–brain barrier (BBB) deteriorates after stroke by develo** diffuse microvascular and neurovascular dysfunction...
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Tumor microenvironment in a minipig model of spinal cord glioma
BackgroundSpinal cord glioma (SCG) is considered an orphan disease that lacks effective treatment options with margins that are surgically...
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Fenestrated Capillary and Dynamic Neuro-Glial-Vascular Reorganization of the Adult Neurohypophysis
It is well known that dynamic structural reorganization occurs in the adult mammalian neurohypophysis (NH) in response to chronic physiological...
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Correction to: Activation of Sigma-1 Receptor Enhanced Pericyte Survival Via the Interplay between Apoptosis and Autophagy: Implications for Blood–Brain Barrier Integrity in Stroke
In the original publication of this article, the representative western blot images of β-actin in Fig. 3e was presented repeatedly in Fig. 7b due to...
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Retinal mid-peripheral capillary free zones are enlarged in cognitively unimpaired older adults at high risk for Alzheimer’s disease
BackgroundCompared to standard neuro-diagnostic techniques, retinal biomarkers provide a probable low-cost and non-invasive alternative for early...
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Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice
Fibrotic scar tissue formation occurs in humans and mice. The fibrotic scar impairs tissue regeneration and functional recovery. However, the origin...
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Targeting Pericytes for Functional Recovery in Ischemic Stroke
Pericytes surrounding endothelial cells in the capillaries are emerging as an attractive cell resource, which can show a large variety of functions...
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Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease
Extensive effort has been made studying retinal pathology in Alzheimer’s disease (AD) to improve early noninvasive diagnosis and treatment....
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The Transcriptional Landscape of Pericytes in Acute Ischemic Stroke
The current treatment options for ischemic stroke aim to achieve reperfusion but are time critical. Novel therapeutic approaches that can be given...
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Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity
BackgroundReduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are...
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Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Mild traumatic brain injury (mTBI) induced by low-intensity blast (LIB) is a serious health problem affecting military service members and veterans....
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Regional Onco-Sphere: Lymph Node Metastasis
During cancer metastasis, cancer cells spread by dissemination into nearby normal tissue mostly via two major routes (i) lymph nodes and (ii) blood...
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Single-cell analysis of adult human heart across healthy and cardiovascular disease patients reveals the cellular landscape underlying SARS-CoV-2 invasion of myocardial tissue through ACE2
BackgroundThe distribution of ACE2 and accessory proteases (ANAD17 and CTSL) in cardiovascular tissue and the host cell receptor binding of severe...
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TIMP-3 Alleviates White Matter Injury After Subarachnoid Hemorrhage in Mice by Promoting Oligodendrocyte Precursor Cell Maturation
Subarachnoid hemorrhage (SAH) is associated with high mortality and disability rates, and secondary white matter injury is an important cause of poor...
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Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization
ObjectiveStatins pleiotropically provide additional benefits in reducing atherosclerosis, but their effects on intraplaque angiogenesis (IPA) and...
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Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity
Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally activated ion channel. TRPV4 has been implicated in tumor...
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Blood-spinal cord barrier disruption in degenerative cervical myelopathy
Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord dysfunction in the aging population. Significant neurological...
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Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain
BackgroundExposure to inflammation during pregnancy can predispose to brain injury in premature infants. In the present study, we investigated the...
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Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity
Platelet-derived growth factor-B (PDGF-B) is a main factor to promote adipose tissue angiogenesis, which is responsible for the tissue expansion in...
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TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association
BackgroundThe breast cancer microenvironment promotes tumor vascularization through the complex interactions involving tumor-associated fibroblasts...
