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Construction of Imatinib Controlled Release Film-Forming System Based on Drug Ion-Pair and Oligomeric Ionic Liquids for the Long Local Therapy of Cutaneous Melanoma
An imatinib controlled release film-forming system (FFS) was developed based on the drug ion-pair and newly designed oligomeric ionic liquids (OILs)...
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Classification of Nanomaterials (Carbon, Metals, Polymers, Bio-ceramics)
One of the most cutting-edge materials available today is nanomaterials. In recent years, nanomaterials have captured the interest of a majority of...
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Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique
Hot melt extrusion (HME) has been used for the formulation of topical solid lipid nanoparticle (SLN) gel without using any other size reduction...
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Protein Based Amorphous Solid Dispersion: a Case Study Investigating Different Whey Proteins at High Drug Loading
PurposeWhey protein isolate (WPI) has previously been shown to be a promising new excipient for the development of amorphous solid dispersions (ASD)...
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Biomimetic Mineralization of Electrospun PCL-Based Composite Nanofibrous Scaffold for Hard Tissue Engineering
Develo** electrospun nanofibrous scaffolds has been expanded as a promising strategy in the field of bone tissue engineering owing to its...
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Clinical and Structural Highlights for Nanoparticle Formulations of Anticancer Drugs
Safety and efficacy are crucial to achieving clinical authorization to use anticancer drugs. Nevertheless, at the regulatory level, anticancer drugs...
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Generation of Ophthalmic Nanosuspension of Prednisolone Acetate Using a Novel Technology
PurposePrednisolone Acetate (PAC) is currently marketed as micronized ophthalmic suspension. The microsuspension has poor dose accuracy and efficacy...
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Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies
Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa . However,...
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Advancements of hot-melt extrusion technology to address unmet patient needs and pharmaceutical quality aspects
BackgroundHot-melt extrusion (HME) significantly affects pharmaceutical manufacturing by enhancing drug solubility and bioavailability. Advancements...
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Precipitation Technologies for Nanoparticle Production
Precipitation technologies have been widely studied for nanoparticle production because they provide more control over particle size, shape, and...
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Integrated Continuous Process Design for Crystallisation, Spherical Agglomeration, and Filtration of Lovastatin
PurposeThis work seeks to improve the particle processability of needle-like lovastatin crystals and develop a small-footprint continuous...
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Carrageenan Based Films
Among bio-based polymers, the sulfated polysaccharide carrageenan has been considered as an attractive material in various applications as additive...
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Quality Control and Regulatory Landscape of 3D-Printed Drug Products
This chapter provides an overview of the evolving landscape concerning the quality control (QC) and regulatory considerations surrounding 3D-printed...
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Exemestane encapsulated copolymers L121/F127/GL44 based mixed micelles: solubility enhancement and in vitro cytotoxicity evaluation using MCF-7 breast cancer cells
PurposeThe present study aimed to develop a novel therapeutic approach for controlled delivery of exemestane (EXE) to cancer cells using...
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A Customized Screening Tool Approach for the Development of a Self-Nanoemulsifying Drug Delivery System (SNEDDS)
The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying...
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Targeted Delivery of Natural Products
Natural products have been a precious source of innumerable bioactive chemicals due to which many conventional therapies and remedies have been...
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Cosolvent and Complexation Systems
Cosolvent and polyethylene glycol (PEG)-based solubilization techniques for the delivery of poorly soluble drugs are discussed in this chapter. The...
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The Effect of Process Variables and Binder Concentration on Tabletability of Metformin Hydrochloride and Acetaminophen Granules Produced by Twin Screw Melt Granulation with Different Polymeric Binders
In twin screw melt granulation, granules are produced by passing mixtures of drug substances and polymeric binders through twin screw extruder such...
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Microfluidics-on-a-chip for designing celecoxib-based amorphous solid dispersions: when the process shapes the product
The fundamental idea underlying the use of amorphous solid dispersions (ASDs) is to make the most of the solubility advantage of the amorphous form...
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Enhancing Atorvastatin In Vivo Oral Bioavailability in the Presence of Inflammatory Bowel Disease and Irritable Bowel Syndrome Using Supercritical Fluid Technology Guided by wbPBPK Modeling in Rat and Human
Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are common disorders that can change the body’s physiology and drugs...
