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Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo
BackgroundThe low extracellular pH (pH e ) of tumors resulting from glycolytic metabolism is a stress factor for the cells independent from...
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Isolating Primary Tumor Cells from the MMTV-PyMT Mouse Model and Their Use in Develo** an Orthotopic Mouse Model of Breast Cancer
To study the effect of the immunologically unimpaired microenvironment on tumor progression as well as the efficacy of therapies requiring a...
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S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis
BackgroundPIK3CA mutations are frequent in human breast cancer. Pik3ca H1047R mutant expression in mouse mammary gland promotes tumorigenesis. TP53 ...
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Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer
BackgroundBreast cancer (BC) is the most common cancer in women, with triple negative BC (TNBC) accounting for 20% of cases. While early detection...
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POstmastectomy radioThErapy in Node-posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a study protocol for a multicenter prospective phase III randomized controlled trial
BackgroundVarious randomized trials have demonstrated that postmastectomy radiotherapy (RT) to the chest wall and comprehensive regional nodal areas...
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Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns
Whole chromosome and arm-level copy number alterations occur at high frequencies in tumors, but their selective advantages, if any, are poorly...
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Lasofoxifene as a potential treatment for aromatase inhibitor-resistant ER-positive breast cancer
BackgroundBreast cancers treated with aromatase inhibitors (AIs) can develop AI resistance, which is often driven by estrogen receptor-alpha (ERα/ ESR1...
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Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs
Programmed cell death (PCD) plays an important role in many aspects of individual development, maintenance of body homeostasis and pathological...
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RSK3 switches cell fate: from stress-induced senescence to malignant progression
BackgroundTGFβ induces several cell phenotypes including senescence, a stable cell cycle arrest accompanied by a secretory program, and...
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In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence
Recurrent cancer cells that evade therapy is a leading cause of death in breast cancer patients. This risk is high for women showing an...
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Can internal mammary lymph nodes irradiation bring survival benefits for breast cancer patients? A systematic review and meta-analysis of 12,705 patients in 12 studies
ObjectiveTo evaluate the effect of prophylactic irradiation of internal mammary lymph nodes in breast cancer patients.
MethodsThe computer searched...
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Re-expression of miR-200s in claudin‐low mammary tumor cells alters cell shape and reduces proliferation and invasion potentially through modulating other miRNAs and SUZ12 regulated genes
BackgroundMicroRNAs are a class of non-coding RNAs that regulate gene expression through binding to mRNAs and preventing their translation. One...
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Exposure to Organochlorine Pesticides and Female Breast Cancer Risk According to Molecular Receptors Expression: a Systematic Review and Meta-analysis of Epidemiological Evidence
Purpose of ReviewOrganochlorine pesticides (OCP) have been proposed as potential mammary carcinogens since they interact with steroid signaling...
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Tumors of the Musculoskeletal System
These generic terms indicate an abnormal tumor-like overgrowth of a normal or abnormal tissue. Dysplasia is a non-neoplastic lesion and this is cured...
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The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors
Today, adoptive cell therapy has many successes in cancer therapy, and this subject is brilliant in using chimeric antigen receptor T cells. The CAR...
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Engineering and studying syngeneic animal tumors and Large animal endogenous tumor models
In this review, we discussed mice model and canine model which are used to study different types of cancer. Mice models are the most commonly used...
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Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell...
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The association between adiposity and anti-proliferative response to neoadjuvant endocrine therapy with letrozole in post-menopausal patients with estrogen receptor positive breast cancer
The impact of adiposity on the efficacy of endocrine treatment in patients with estrogen receptor positive breast cancer is poorly investigated....
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Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors
Emphasizing the dynamic processes between cancer and host immune system, the initially discovered concept of cancer immunosurveillance has been...
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Estrogen receptor status heterogeneity in breast cancer tumor: role in response to endocrine treatment
Tumor heterogeneity affects diagnosis, prognosis and response to therapy. Heterogeneity is found in both normal and neoplastic human mammary gland....
