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Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats
Leptin resistance in endothelial cells leads to vascular endothelial dysfunction, which is the beginning and crucial link of atherosclerosis....
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BDNF Gene as a Precision Skill of Obesity Management
The scarcity of the results obtained for the treatment of obesity leads us to consider new strategies, contemplating all the factors involved in the...
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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes
Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here,...
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Genome Editing and Obesity
Defined as a condition of body fat excess leading to significant morbidity, obesity is a chronic metabolic illness associated with a significant...
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Influence of the Breeding System on the Nucleotides Variability of Melanocortin-4 Receptor (MC4r) Gene in Chinchillas (Chinchilla lanigera)
AbstractThe melanocortin-4 receptor (MC4r) located in the hypothalamus is an important element of the signaling pathway involved in the regulation of...
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Acetyl-11-Keto-Beta-Boswellic Acid Has Therapeutic Benefits for NAFLD Rat Models That Were Given a High Fructose Diet by Ameliorating Hepatic Inflammation and Lipid Metabolism
Acetyl-11-keto-beta-boswellic acid (AKBA), a potent anti-inflammatory compound purified from Boswellia species, was investigated in a preclinical...
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Involvement of the vagus nerve and hepatic gene expression in serum adiponectin concentrations in mice
Several humoral factors, such as adiponectin and urate, have been suggested to affect metabolic syndromes. Previously, we reported a reduction in...
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Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics
Atherosclerosis, one of the life-threatening cardiovascular diseases (CVDs), has been demonstrated to be a chronic inflammatory disease, and...
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Modulation of endoplasmic reticulum stress via sulforaphane-mediated AMPK upregulation against nonalcoholic fatty liver disease in rats
Nonalcoholic fatty liver disease (NAFLD) is a major health concern. Endoplasmic reticulum (ER) stress, inflammation, and metabolic dysfunctions may...
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Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice
Inflammation may contribute to multiple brain pathologies. One cause of inflammation is lipopolysaccharide/endotoxin (LPS), the levels of which are...
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Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning
Hepatocellular carcinoma (HCC) markedly enhances liver secretion of fibroblast growth factor 21 (FGF-21), a hepatokine that increases brown and...
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Linking mitochondrial dynamics and fertility: promoting fertility by phoenixin through modulation of ovarian expression of GnRH receptor and mitochondrial dynamics proteins DRP-1 and Mfn-2
Obesity is linked to reproductive disorders. Novel neuropeptide phoenixin demonstrated many therapeutic actions. In this study, we aim to evaluate...
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Transcriptional changes in multiple endocrine organs from lethal cases of COVID-19
AbstractAltered circulating hormone and metabolite levels have been reported during and post-COVID-19. Yet, studies of gene expression at the tissue...
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Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome
BackgroundMetabolic syndrome (MetS) refers to a cluster of co-existing cardio-metabolic risk factors, including visceral obesity, dyslipidemia,...
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Retinal determination gene networks: from biological functions to therapeutic strategies
The retinal determinant gene network (RDGN), originally discovered as a critical determinator in Drosophila eye specification, has become an...
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Eccentric and concentric exercises induce different adaptions in adipose tissue biology
Alterations in adipose tissue (AT) metabolism related to inflammation and adipokine’s production lead to perturbations in its capacity to store...
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Chemical Probes for Histamine Receptor Subtypes
Ligands with different properties and different selectivity are highly needed for in vitro and in vivo studies on the (patho)physiological influence...
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Effect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women: a pilot study
IntroductionMetformin may provide a therapeutic benefit in different types of malignancy.
PurposeWe aimed at evaluating the effect of metformin as...
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Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort
Mutations in the melanocortin 4 receptor gene ( MC4R ) are associated with obesity but little is known about the prevalence and impact of such...
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Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: Role of SIRT-1 / adipokines / PPARγ and IGF-1
BackgroundAdiposity and non-alcoholic fatty liver disease (NAFLD) are common characteristics of metabolic syndrome (MS). Understanding the underlying...
