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Health and Racial Disparity in Breast Cancer
Breast cancer is the most common noncutaneous malignancy and the second most lethal form of cancer among women in the United States. It currently...
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Current and Future Perspectives of Combining Chemotherapy and Stereotactic Body Radiation Therapy with Immunotherapy in the Treatment of Lung Cancer
Lung cancer is a huge public health concern all over the world, including India, and for many years, the gold standard treatment has been the...
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Radiation therapy with phenotypic medicine: towards N-of-1 personalization
In current clinical practice, radiotherapy (RT) is prescribed as a pre-determined total dose divided over daily doses (fractions) given over several...
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Prospective results of concurrent radiation therapy and weekly paclitaxel as salvage therapy for unresectable locoregionally recurrent breast cancer
PurposeTo investigate the efficacy and toxicity of concurrent radiation therapy (RT) and paclitaxel in the treatment of unresectable locoregionally...
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Comparative survival analysis of multiparametric tests—when molecular tests disagree—A TEAM Pathology study
Multiparametric assays for risk stratification are widely used in the management of both node negative and node positive hormone receptor positive...
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Clinical Application of Immunotherapy in the Perioperative Management of Head and Neck Cancer
Immunotherapy has changed the landscape of recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) and is now an essential element...
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Immune recurrence score using 7 immunoregulatory protein expressions can predict recurrence in stage I–III breast cancer patients
BackgroundImmune cells in the tumour microenvironment play an essential role in tumorigenesis. This study aimed to evaluate the immunoregulatory...
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HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function
PurposeLeukaemia remains a major contributor to global mortality, representing a significant health risk for a substantial number of cancer patients....
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Artificial neural network models to predict nodal status in clinically node-negative breast cancer
BackgroundSentinel lymph node biopsy (SLNB) is standard staging procedure for nodal status in breast cancer, but lacks therapeutic benefit for...
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Diffusion, MRI, and Cancer Diagnosis: Physicist’s Outlook
A very elegant application of nuclear magnetic resonance (NMR) phenomenon is imaging the 1HNMR signals emitted from water molecules of human cells...
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The clinical and biological significance of HER2 over-expression in breast ductal carcinoma in situ: a large study from a single institution
BackgroundPrevious studies have reported up to 50% of ductal carcinoma in situ (DCIS), is HER2 positive, but the frequency of HER2-positive invasive...
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Radiation-induced lung toxicity – cellular and molecular mechanisms of pathogenesis, management, and literature review
Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors...
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Prognostic models for breast cancer: a systematic review
BackgroundBreast cancer is the most common cancer in women worldwide, with a great diversity in outcomes among individual patients. The ability to...
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Predictive and prognostic value of ZEB1 protein expression in breast cancer patients with neoadjuvant chemotherapy
BackgroundZinc finger E-box binding homeobox 1 (ZEB1) is a molecule involved in the progression of epithelial-to-mesenchymal transition (EMT) in...
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Neonatal Fc Receptor–Targeted Therapies in Neurology
Autoantibodies are increasingly recognized for their pathogenic potential in a growing number of neurological diseases. While myasthenia gravis...
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Single dose of dexamethasone is not associated with postoperative recurrence and mortality in breast cancer patients: a propensity-matched cohort study
BackgroundDexamethasone is widely used in cancer patients despite the concern that perioperative glucocorticoids may potentially cause...
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The effect of neoadjuvant platinum-based chemotherapy in BRCA mutated triple negative breast cancers -systematic review and meta-analysis
BackgroundTriple negative breast cancers (TNBC) are associated with an aggressive clinical course, earlier recurrence and short survival. BRCA –...
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Preliminary toxicity results using partial breast 3D-CRT with once daily hypo-fractionation and deep inspiratory breath hold
BackgroundTo evaluate the clinical outcomes of patients treated with 3D conformal H ypo-fractionated, deep I nspiratory breath-hold (DIBH), P artial...
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Clonal relatedness in tumour pairs of breast cancer patients
BackgroundMolecular classification of tumour clonality is currently not evaluated in multiple invasive breast carcinomas, despite evidence suggesting...
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Stem-like exhausted and memory CD8+ T cells in cancer
T cells can acquire a broad spectrum of differentiation states following activation. At the extreme ends of this continuum are short-lived cells...
