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The crucial role of SETDB1 in structural and functional transformation of epithelial cells during regeneration after intestinal ischemia reperfusion injury
Su (var) 3–9, enhancer of seste, trithorax (SET)-domain bifurcated histone lysine methyltransferase (SETDB1) plays a crucial role in maintaining...
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Role of syntaxin3 an apical polarity protein in poorly polarized keratinocytes: regulation of asymmetric barrier formations in the skin epidermis
The skin epidermis exhibits an asymmetric structure composed of multilayered keratinocytes and those in the outer layers form two-way physical...
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Nectins and Nectin-like molecules drive vascular development and barrier function
Angiogenesis, barriergenesis, and immune cell migration are all key physiological events that are dependent on the functional characteristics of the...
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Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids
Isolation of tissue-specific fetal stem cells and derivation of primary organoids is limited to samples obtained from termination of pregnancies,...
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The lncRNA HOTAIR: a pleiotropic regulator of epithelial cell plasticity
The epithelial-to-mesenchymal transition (EMT) is a trans-differentiation process that endows epithelial cells with mesenchymal properties, including...
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TFAM-Mediated mitochondrial transfer of MSCs improved the permeability barrier in sepsis-associated acute lung injury
Vascular endothelial cell barrier disruption is a hallmark of sepsis-induced acute lung injury (ALI). Mesenchymal stem cells (MSCs)-based therapy has...
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Effects of Intestinal M Cells on Intestinal Barrier and Neuropathological Properties in an AD Mouse Model
Intestinal microfold cells (M cells) play a critical role in the immune response of the intestinal mucosa by actively taking up antigens,...
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Epithelial-Mesenchymal Plasticity: A Link Between Inflammation and Cancer Metastasis
Epithelial-mesenchymal plasticity (EMP) defines the ability of cells to transdifferentiate between epithelial and mesenchymal states. Tumor cells...
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DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction
BackgroundTight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for...
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Transcriptional Levels of Intercellular Junction Proteins in an Alveolar Epithelial Cell Line Exposed to Irradiation or Bleomycin
We performed a comparative study of the effects of X-ray irradiation and bleomycin on the mRNA levels of E-cadherin and tight junction proteins...
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Staphylococcus aureus populations from the gut and the blood are not distinguished by virulence traits—a critical role of host barrier integrity
BackgroundThe opportunistic pathogen Staphylococcus aureus is an asymptomatically carried member of the microbiome of about one third of the human...
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The genetics of monogenic intestinal epithelial disorders
Monogenic intestinal epithelial disorders, also known as congenital diarrheas and enteropathies (CoDEs), are a group of rare diseases that result...
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The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several states across the epithelial–mesenchymal landscape, thereby...
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Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1
Children are less likely than adults to suffer severe symptoms when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while...
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Effects of Mast Cells Induced by NSAIDs Impair Intestinal Epithelial Barrier Function In Vivo and In Vitro
To explore the correlation between altered expression of mast cells and PAR-2 and impaired mucosal barrier in NSAIDs enteropathy through animal and...
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Diosmetin alleviates acute lung injury caused by lipopolysaccharide by targeting barrier function
Acute lung injury (ALI) is an acute and devastating disease caused by systemic inflammation e.g. patients infected with bacteria and viruses such as...
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Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
BackgroundAlbuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism...
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Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis
BackgroundIntestinal barrier dysfunction, which is associated with reactive enteric glia cells (EGCs), is not only a result of early sepsis but also...
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Hypoxia-Mediated Upregulation of Xanthine Oxidoreductase Causes DNA Damage of Colonic Epithelial Cells in Colitis
Xanthine oxidoreductase (XOR) serves as the primary source of hydrogen peroxide and superoxide anions in the intestinal mucosa. However, its specific...
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An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells
Immunoglobulin A (IgA) secretion by plasma cells, terminally differentiated B cells residing in the intestinal lamina propria, assures microbiome...
