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Clinical evaluation of serum α-fetoprotein and circulating immune complexes as tumour markers of hepatocellular carcinoma
To evaluate the diagnostic application of serum alpha-fetoprotein (AFP) and circulating immune complexes (CICs), AFP, 3% polyethylene glycol...
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Hirudin: The Famous Anticoagulant Agent
It has been known for a long time already that medicinal leeches (Hirudo medicinalis) contain a substance with anticoagulant properties. In early... -
Synthetic Thrombin Inhibitors as Anticoagulants Pharmacological Aspects
Thromboembolic disorders are a major cause of morbidity and mortality in industrialized countries. For prophylaxis of thrombosis at present the... -
Anti-Phosphatidylserine Monoclonal Antibody: Structural Template for Studying Lipid-Protein Interactions and for Identificationo of Phosphatidylserine Binding Proteins
Although phosphatidylserine (PS) is an essential component for the formation of membrane bilayers, it has been shown to contribute to many regulatory... -
Role of cellular proteinases and their protein inhibitors in inflammation
If immunological events are the trigger for inflammation, then proteinases provide the resultant explosions. The classic signs of inflammation:... -
Anticoagulants, Antithrombotic and Thrombolytic Agents
Thrombi are blood clots that form within the blood stream. Their presence is always pathologic. They can cause disease locally or can break loose... -
Acrosin, the peculiar sperm-specific serine protease
The sperm enzyme acrosin has long been known as one of the key enzymes in the mammalian fertilization process. Elucidation of primary structures of...
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Deutsche Gesellschaft für Pharmakologie und Toxikologie
Already in 1902 Garrod the founder of modern biochemical genetics, postulated that abnormal reactions to drugs and food are caused by genetic... -
Drug Design
The title of this talk is “Drug Design”. I will focus on the design of peptides. It is a very large topic and an attempt to cover it completely is...