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DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine learning, Mendelian randomization, eQTL and mQTL data
BackgroundIntracranial aneurysms (IAs) pose a significant and intricate challenge. Elucidating the interplay between DNA methylation and IA...
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Identifying biases and their potential solutions in human microbiome studies
Advances in DNA sequencing technology have vastly improved the ability of researchers to explore the microbial inhabitants of the human body....
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A historical step**-stone path for an island-colonizing cactus across a submerged “bridge” archipelago
Here we use population genomic data (ddRAD-Seq) and ecological niche modeling to test biogeographic hypotheses for the divergence of the...
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The genetic variability of grapevine Pinot gris virus (GPGV) in Australia
Grapevine Pinot gris virus (GPGV; genus Trichovirus in the family Betaflexiviridae ) was detected in Australia in 2016, but its impact on the...
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Investigating mobile element variations by statistical genetics
The integration of structural variations (SVs) in statistical genetics provides an opportunity to understand the genetic factors influencing complex...
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Intermolecular Interactions and Self-Assembly of Peptide-Based Nanomaterials Against Human Pathogenic Bacteria
Nanomaterial systems composed of polypeptides are inherently hierarchical in their organization: non-covalent interactions displayed by peptide...
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Creating Artificial Viruses Using Self-assembled Proteins and Polypeptides
Viruses are extraordinary entities that have inspired biomolecular engineers to craft artificial versions of them. Recently, multiple efforts have...
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Geno-informatics for Prediction of Virulence and Drug Resistance in Bacterial Pathogens
In recent years, there has been a rapid surge in the number of resistant strains of bacterial pathogens, mainly due to misuse of antibiotics in our...
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The nucleolus of Giardia and its ribosomal biogenesis
G iardia duodenalis is a protozoan intestinal parasite that causes a significant number of infections worldwide each year, particularly in low-income...
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The structural diversity of CACTA transposons in genomes of Chenopodium (Amaranthaceae, Caryophyllales) species: specific traits and comparison with the similar elements of angiosperms
BackgroundCACTA transposable elements (TEs) comprise one of the most abundant superfamilies of Class 2 (cut-and-paste) transposons. Over recent...
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Towards targeting transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically deemed ‘junk DNA’, recent technological advancements have...
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Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome
BackgroundThe intestinal microbiota plays a crucial role in protecting the host from pathogenic microbes, modulating immunity and regulating...
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Ofatumumab and Granzyme B as immunotoxin against CD20 antigen
Anti‐CD20 antibodies such as ofatumumab has demonstrated efficacy in relapsed/refractory chronic lymphocytic leukemia, are among the most successful...
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Staying Ahead of the Game: How SARS-CoV-2 has Accelerated the Application of Machine Learning in Pandemic Management
In recent years, machine learning (ML) techniques have garnered considerable interest for their potential use in accelerating the rate of drug...
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Overlap** genes in natural and engineered genomes
Modern genome-scale methods that identify new genes, such as proteogenomics and ribosome profiling, have revealed, to the surprise of many, that...
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Sequencing and characterizing short tandem repeats in the human genome
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human genome that are composed of repeated copies of a 1–6-bp motif. Over...
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Complete genomic sequence of crow-dipper mosaic-associated virus, a novel macluravirus infecting Pinellia ternata
A new macluravirus infecting Pinellia ternata in China was identified by high-throughput sequencing (HTS) and tentatively named “crow-dipper...
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Common Techniques Used for Automated Diagnosis in Medical Microbiology
Several manual activities have undergone significant changes by introduction of automated techniques, which have unquestionably improved performance....
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Innovative Strategies in Drug Discovery and Pharmacoinformatics
Drug discovery comprises all the activities involved in transforming a compound from a drug candidate to a product approved for marketable form and...
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The application of long-read sequencing in clinical settings
Long-read DNA sequencing technologies have been rapidly evolving in recent years, and their ability to assess large and complex regions of the genome...
